1/1 NADIA U24 Administrative Core

摘要 1/1 U24 NADIA管理核心-摘要 这是第二次更新的神经生物学的青少年饮酒在成年（NADIA）管理 核心（NADIA管理核心-U24，RFA-AA-20-004）。行政核心提供组织和 科学的领导，以实现我们的联盟的目标：阐明复杂的大脑中的持续变化 青少年酒精暴露后的功能行为关系。青少年酗酒和极端饮酒 是常见的，虽然许多因素有助于人类大脑发育和青少年时期的酒精使用- 然而，动物模型对于理解酒精暴露对大脑的具体后果至关重要。 大脑和行为在这个关键的发展时期。在过去的几年中，NADIA 发现青少年间歇性乙醇（AIE）导致多种行为，神经化学和 成年期生理病理学。机制研究表明，这些AIE诱导的变化可能 通过靶向特定的神经传递、神经炎症或表观遗传调节来预防或逆转 基因。该联盟一直非常富有成效，正如我们最近的文献综述所证明的那样， 200篇文章为了促进和推动持续的进展，NADIA行政核心是主要的 作为联盟的组织单位，并作为科学核心，八个研究中心之间的联系， 组成部分，NADIA指导委员会，外部咨询委员会和NIAAA。行政 核心组织所有联盟活动，包括务虚会，进度报告和外部咨询委员会 核心和组件的评估。行政核心通过以下方式确保持续不断的进步 便于通信并促进组件和核心之间的数据集成。核心 制定科学和概念主题以及建议的操作程序， 件.核心为联盟生成的所有出版物提供了存储库。最后，核心 促进NADIA生成的数据的传播和翻译，部分是通过与 国家酒精和青少年神经发育联盟（NCANDA）和其他酒精研究 组此次NADIA更新完全符合RFA的分子机制和翻译目标， 对青少年饮酒的成人精神病理学的治疗干预的发展。 了解未成年人饮酒对成年人神经生物学的影响对指导公共卫生非常重要 计划，而NADIA管理核心为整个联盟的此类发现创造了协同效应。

ABSTRACT 1/1 U24 NADIA ADMINISTRATIVE CORE - SUMMARY This is the second renewal of the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Administrative Core (NADIA Administrative Core-U24, RFA-AA-20-004). The Administrative Core provides organizational and scientific leadership to achieve the goal of our Consortium: to elucidate persistent changes in complex brain function-behavior relationships following adolescent alcohol exposure. Adolescent binge and extreme drinking are common, and while many factors contribute to human brain development and alcohol use during adoles- cence, animal models are critical for understanding the specific consequences of alcohol exposure on the brain and behavior during this crucial developmental period. In the previous funding periods, the NADIA discovered that adolescent intermittent ethanol (AIE) led to multiple behavioral, neurochemical and physiological patholo-gies in adulthood. Mechanistic studies revealed that these AIE-induced changes could be prevented or re-versed by targeting specific neurotransmission, neuroinflammation, or epigenetic regulation of genes. The Consortium has been very productive, as evidenced by our recent literature reviews and over 200 publications. To promote and facilitate continued progress, the NADIA Administrative Core is the main organizational unit of the Consortium and serves as the liaison between the Scientific Core, the eight Research Components, the NADIA Steering Committee, the External Advisory Board, and the NIAAA. The Administrative Core organizes all Consortium activities including retreats, progress reports and External Advisory Board evaluations of cores and components. The Administrative Core ensures consistent and forward progress by facilitating communica-tion and promoting integration of data among the components and cores. The Core develops scientific and conceptual themes as well as recommended operating procedures that cross components. The Core provides a repository for all publications generated by the Consortium. Finally, the Core facilitates dissemination and translation of NADIA-generated data, in part by targeted interactions with the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and other alcohol research groups. This NADIA renewal exactly fulfills the molecular mechanism and translation goals of this RFA leading to development of therapeu-tic interventions of adult psychopathologies of adolescent alcohol consumption. Understanding the impact of underage drinking on adult neurobiology is important to guide public health initiatives, and the NADIA Adminis-trative Core creates synergies for such discoveries across the Consortium.