EPIDEMIOLOGICAL AND GENETIC STUDIES OF ALS/PD COMPLEX OF GUAM

这一项目代表了进一步阐明病因的努力。 肌萎缩侧索硬化症(ALS)的高发 关岛上的帕金森痴呆症(PD)。一位病人- 对照前瞻性研究(注册)成立于1958年。这个 登记处的目标是确定(1)是否 ALS和PD患者的亲属患上ALS和PD的风险更高 疾病比对照的亲属和(2)是否有家族史 发生的情况确实存在，以确定遗传的程度 与疾病的病因学有关。二十五年 已完成对登记处的后续分析， 结果已经公布。目前正在维护这些登记处 用于未来的后续研究。 这项研究的其他目的是：1)研究遗传 以及导致极高发病率的流行病学因素 肌萎缩侧索硬化症和帕金森病痴呆(ALS/PD) 关于关岛；2)评估各种已建立的 正常关岛人的遗传和人类学标记 并与ALS/PD患者进行比较；以及 3)确定瘫痪后制动的效果。 骨密度。

This project represents further efforts to elucidate the etiology of high incidence of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism Dementia (PD) on the island of Guam. A patient- control prospective study (Registry) was established in 1958. The objective of the registry has been to determine (1) whether relatives of ALS and PD patients have higher risk for developing the disease than relatives of controls and (2) if familial occurrence does exist, to determine the extent of genetic involvement in the etiology of the disease. A twenty-five year follow-up analysis of the registry has been concluded and the results were published. The registries are now being maintained for future follow-up studies. Other objectives of this study are: 1) to investigate the genetic and epidemiological factors contributing to the very high incidence of Amyotrophic Lateral Sclerosis and Parkinsonism Dementia (ALS/PD) on Guam; 2) to evaluate the distribution of the various established genetic and anthropological markers among the normal Guamanian population and compare them with those of the ALS/PD patients; and 3) to ascertain the effects of immobilization due to paralysis on bone density.