INVESTIGATIONS OF OSTEOARTHRITIS AND BONE LOSS

骨丢失和骨关节炎是两个主要年龄之一。 人类骨骼的相关变化。即使这些变化是 被认为是衰老固有的普遍现象，它们可能会导致 使人丧失能力的疾病。晚期骨质流失可能导致骨质疏松症和 频发骨折。在生命的第四个十年的某个时候， 人类的骨骼开始失去骨骼。也就是说，骨量在 与骨量的关系。在板状骨骼中，骨是从 骨内膜表面。由于皮质骨壳变薄， 骨骼失去其机械完整性，更容易骨折。这个 脊柱的骨小梁质量也随着年龄的增长而减少。这个 椎板密度降低，对垂直方向失去抵抗力 压缩应力较大，更容易发生椎体塌陷。 椎体压缩骨折和股骨颈骨折是 最严重的骨质流失后果。以下是以下骨骼部位 本研究涉及：手腕、尺骨、桡骨和脊椎 纵队。该项目涉及流行病学、遗传学和 骨丢失的纵向方面(1) 巴尔的摩纵向研究，(2)正常成年关岛人样本 (Chamorros)，(3)肌萎缩侧索症患者 关岛硬化症/帕金森病痴呆复合体，(4)确定骨骼 长跑运动员之间的矿物质差异(至少跑40% 每天数英里)和相对不活跃的正常对照组，以及(5)骨骼研究 大鼠骨密度和肌肉活动对骨的影响。

Bone loss together with osteoarthritis is one of the two principal age related changes of the human skeleton. Even though these changes are considered universal phenomena inherent to aging, they may result in incapacitating ailments. Advanced bone loss may result in osteoporosis and frequent bone fractures. At some time during the fourth decade of life, the human skeleton begins to lose bone. That is, bone mass decreases in relation to bone volume. In tabular bones, bone is resorbed from the endosteal surface. Because of the thinning of the cortical bone shell, bones lose their mechanical integrity and fracture more readily. The trabecular bone mass of the vertebral column also decreases with age. The vertebral plates decrease in density, lose resistance to vertical compression stress and are more vulnerable to vertebral collapse. Vertebral compression fractures and fractures of the femoral neck are the most serious consequences of bone loss. The following skeletal sites are involved in the present study: hand-wrist, ulna and radius and vertebral column. This project deals with the epidemiological, genetic and longitudinal aspects of bone loss (1) among the participants of the Baltimore Longitudinal Study, (2) in a sample of normal adult Guamanians (Chamorros), (3) among patients afflicted with Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex of Guam, (4) to ascertain bone mineral differences between long distance runners (running at least 40 miles daily) and relatively inactive normal controls, and (5) study of bone mineral density and effect of muscular activity on bone in rats.