EPIDEMIOLOGICAL AND GENETIC STUDIES OF ALS/PD COMPLEX OF GUAM

关岛上的侧索硬化症(ALS)和帕金森氏症(PD)。一个 患者对照前瞻性研究(REGISTY)成立于1958年。这个 对1967年公布的登记处数据的初步分析和后续行动 1986年发表的分析显示，在关岛发现的这些疾病是 有很强的家族性。也就是说，患者的亲属患癌症的风险更高。 与对照组相比，发生该病的人数更多。下一个问题是 答案是这种家族性疾病是由于遗传还是 环境因素。这项研究的具体目标是：a) 确定基因参与的程度在高发病率 肌萎缩侧索硬化症和帕金森病痴呆通过：(1) 1958年以来所有确诊患者的家系分离分析 和(2)通过父母双方，其中一人的兄弟姐妹关系的分离分析 父母或父母中的任何一方(对照)都不会受到ALS和PD的影响。 B)研究各种已建立的遗传和遗传基因的分布 关岛正常人群的人类学标记及其比较 与肌萎缩侧索硬化症和帕金森病患者的结果一致。C)确定以下方面的影响 瘫痪所致的制动对骨密度影响。

Lateral Sclerosis (ALS) and Parkinsonism (PD) on the island of Guam. A patient-control prospective study (Registry) was established in 1958. The initial analysis of the Registry data published in 1967 and the follow up analysis published in 1986 showed that these diseases as found on Guam are highly familial. That is, relatives of patients have a higher risk for developing the disease than those of controls. The next question to be answered is whether this familial occurrence is due to genetic or environmental factors. The specific objectives of this study are: A) To ascertain the extent of genetic involvement in the high incidence of Amyotrophic Lateral Sclerosis and Parkinsonism Dementia through: (1) segregation analysis of the pedigrees of all patient diagnosed since 1958 and, (2) through segregation analysis of sibships where both parents, one parent or neither of the parents (controls) are affected with ALS and PD. B) To study the distribution of various established genetic and anthropological markers among the normal Guamanian populations and compare them with those of the ALS and PD patients. C) to ascertain the effects of immobilization due to paralysis on bone density.