IN VIVO 170 NMR STUDIES OF CEREBRAL OXYGEN CONSUMPTION

该项目涉及开发一种新的非侵入性方法 用于成像大脑中的氧气消耗。这一新方法 结合了磁共振波谱的优势，它可以 分离大脑中不同代谢物的信号，并 共振成像，它可以将信号定位到定义明确的区域 大脑。 如果吸入17O标记的氧气，17O核磁共振波谱可以分离 并对来自17O标记水的信号进行量化，这是结束 大脑中氧化代谢的产物。这一信号的兴起 直接给出大脑的耗氧率。如果这个 信号被成像，不同区域的耗氧率 可以确定大脑的位置。在目前，空间 该方法的分辨率为0.8cc。 17O核磁共振方法的主要优点之一是 技术是非侵入性的，可以用在人类身上，而且 17O标记的化合物，即氧和水，是非放射性的，以及 无毒。

This project involves the development of a new non-invasive approach for imaging oxygen consumption in the brain. This new approach combines the advantages of magnetic resonance spectroscopy, which can separate signals from different metabolites in the brain, and magnetic resonance imaging, which can localize signals to well-defined regions of the brain. If 17O-labelled oxygen is inhales, 17O NMR spectroscopy can separate and quantitate signals from 17O-labelled water, which is the end product of oxidative metabolism in the brain. The rise of this signal directly gives the rate of oxygen consumption in the brain. If this signal is imaged, the rate of oxygen consumption in different regions of the brain can be determined. At the present time, the spatial resolution of the approach is 0.8 cc. One of the major advantages of the 17O NMR approach is that NMR techniques are non-invasive, and can be used with humans, and that 17O-labelled compounds, i.e., oxygen and water, are non-radioactive, and non-toxic.