CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE RAT

体液和神经因子在脑血调节中的作用 流动和代谢是有争议的。 我们研究了大脑的控制 正常和压力条件下的血液流动和代谢。 我们 最初的工作是用高碳酸血症和脱氧葡萄糖模型进行的， 压力，但研究可以扩展到其他模型的压力，例如， 缺氧、低血糖和戒断慢性饮酒。 我们 初步观察表明，肾上腺髓质是 控制脑血流反应的因素， 高碳酸血症应激 进一步的研究表明，其中一个因素是 δ-阿片肽 此外，最近的研究表明， 通过EDRF对高碳酸血症应激的血流进行药物治疗 （内皮衍生舒张因子）系统，以及交感神经系统。 系统 关于δ-阿片样物质系统， EDRF系统和交感神经系统在激活 高碳酸血症的脑血正在研究中。

The role of humoral and neuronal factors in the control of cerebral blood flow and metabolism is controversial. We studied the control of cerebral blood flow and metabolism under normal and stressful conditions. Our initial work was done with the hypercapnic and deoxyglucose models for stress, but the studies may be extended to other models of stress, e.g., hypoxia hypoglycemia and withdrawal from chronic alcohol consumption. Our initial observations demonstrated that the adrenal medualla was the source of factrs that controlled the response of cerebral blood flow to hypercapnic stress. Further work indicated that one of these factors was a delta-opioid peptide. Also, recent work demonstrated tht the response blood flow to hypercapnic stress is medicated through the EDRF (endothelium derived relaxing factor) system, and the sympathetic nervous system. Further details of the interaction of the delta-opiod system, the EDRF system, and the sympathetic nervous system in the activation of cerebral blood in hypercapnia are under investigation.