课题基金 / 基金详情

EFFICACY OF HYPERIMMUNE PLASMA IN AIDS

EFFICACY OF HYPERIMMUNE PLASMA IN AIDS
超免疫血浆治疗艾滋病的功效
批准号：
3792575
负责人：
I K HEWLETT
金额：
$0.0万
依托单位：
CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3792575
关键词：
AIDS AIDS therapy antiviral antibody human immunodeficiency virus 1 human subject neutralizing antibody passive immunization polymerase chain reaction virus DNA virus RNA virus antigen

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中文摘要
翻译
从健康的、感染了HIV-1的人身上采集高免疫血浆 中和抗体效价高的个人，并接受 给50名艾滋病患者。所有患者都接受了病毒抗体的监测， 用聚合酶链式反应检测抗原和病毒核酸。外周血单核细胞 细胞(PBMC)和血清是从这些人和从一个 一组接受安慰剂治疗的个体。病毒载量正在被量化 淋巴细胞DNA、RNA聚合酶链式反应和血清RNA聚合酶链式反应。初步 结果表明，尽管可能有基于 血清p24抗原、病毒DNA水平未见下降。
英文摘要
Hyperimmune plasma was collected from healthy, HIV-1 infected individuals with high titers of neutralizing antibodies and administered to 50 AIDS patients. All patients were monitored for viral antibodies, antigen and viral nucleic acid by PCR. Peripheral blood mononuclear cells (PBMCs) and sera were collected from these individuals and from a group of placebo treated individuals. Viral load is being quantitated by DNA and RNA PCR on the lymphocytes and RNA PCR on serum. Preliminary results suggest that although there may be protection based on the levels of serum p24 antigen, viral DNA levels were not decreased.
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会议论文
VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
EFFICACY OF PASSIVE IMMUNOTHERAPY IN AIDS ASSESSED BY PCR
IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN
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