GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

内毒素反应型(LPS(R))和缺陷型(LPS(D)) 不同品系的C3H小鼠在细菌能力上有很大的差异 单磷脂A(MPL)灭活抑制性T细胞(Ts) 暴露于III型肺炎球菌后产生的功能 多糖(SSS-III)。这表明激活的T细胞 小鼠在以下方面有所不同：(A)细胞表面受体 MPL的结合和随后的内化和/或(B)存在 一种对以下物质的失活极为敏感的生化途径 MPL. 铜绿假单胞菌内毒素的主要抗体亚型 在几个品系的近交系小鼠中，有一种是IgG3。通过以下方式治疗 无论如何，γ-干扰素导致IgG2a抗体增加 主要组织相容性复合体(MHC)单倍型。因此，同型的 用这种抗原免疫的小鼠产生的模式不是MHC 受到限制，受淋巴因子的影响很大。

Lipopolysaccharide-responsive (LPS(r)) and LPS-defective (LPS(d)) strains of C3H mice differ greatly in the capacity of bacterial monophosphoryl lipid A (MPL) to inactivate suppressor T cell (Ts) function generated after exposure to Type III pneumococcal polysaccharide (SSS-III). This suggests that the activated Ts of such mice differ with respect to (a) a cell surface receptor required for the binding and subsequent internalization of MPL and/or (b) the presence of a biochemical pathway that is extremely sensitive to inactivation by MPL. The predominant isotype of antibody against Pseudomonas aeruginosa LPS in several strains of inbred mice is IgG3. Treatment with Gamma-interferon resulted in an increase in IgG2a antibody, regardless of major histocompatibility complex (MHC) haplotype. Thus the isotypic pattern produced in mice immunized with this antigen is not MHC restricted and is influenced greatly by lymphokines.