MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS

4天获得的毛野豌豆凝集素粘附Lyt-1+脾细胞 在用最佳免疫原性剂量（0.5 微克III型肺炎球菌多糖（SSS-III）， 增加了小鼠对SSS的抗体反应的幅度- III转移给同样免疫的接受者后 抗原;然而，证明这种增强的能力 这在很大程度上取决于这些细胞何时被转移， 免疫接种者。 凝集素贴壁细胞增强了 无胸腺裸鼠（nu/nu）对SSS-III的抗体应答，以及 废除了表达-但不是诱导-低剂量 免疫麻痹，一种由免疫系统介导的无反应性形式， 抑制性T细胞 这些发现与 通常归因于放大器的作用，而不是 反抑制剂T细胞

Vicia villosa lectin-adherent Lyt-1+ spleen cells, obtained 4 days after immunization with an optimally immunogenic dose (0.5 microgram of Type III pneumococcal polysaccharide (SSS-III), increased the magnitude of the antibody response of mice to SSS- III upon transfer to recipients also immunized with the same antigen; however, the ability to demonstrate such enhancement depended greatly upon when such cells were transferred relative to immunization of recipients. Lectin-adherent cells augmented the antibody response of athymic nude (nu/nu) mice to SSS-III, and abrogated the expression--but not the induction--of low-dose immunological paralysis, a form of unresponsiveness mediated by suppressor T cells. These finds are consistent with effects usually attributed to the action of amplifier, rather than contrasuppressor, T cells.