GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

B6.C同源品系的小鼠，具有来自 高应答BALB/cByJ(C)小鼠的遗传背景 低反应C57BL/6ByJ(B6)小鼠，检测它们的能力 对III型肺炎球菌多糖(SSS-III)产生抗体反应 α1产生细菌(Leuconostoc)葡聚糖的3个决定簇 B-1355。所获得的结果证实了使基因呈阳性的 对SSS-III响应度的贡献位于不同的 染色体，即第1、3、4、5和9号染色体。至少还有一个基因 也会影响对这种抗原的反应性；它与 尚未被分配到特定染色体的H-17基因座。基因 在1，4和5号染色体上发现影响 对葡聚糖B-1355的抗体反应。其中一些基因似乎是 在它们的作用模式中是抗原特异性的；然而，其他的不是因为 它们对SSS-III和SSS-III的抗体反应都有影响 右旋糖苷B-1355。

B6.C congenic strains of mice, possessing chromosomal segments from high-responding BALB/cByJ (C) mice on the genetic background of low-responding C57BL/6ByJ (B6) mice, were examined for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the alpha 1 yield 3 determinant of bacterial (Leuconostoc) dextran B-1355. The results obtained affirmed that genes making a positive contribution to responsiveness to SSS-III are located on different chromosomes, i.e., chromosomes 1,3,4,5, and 9. At least one other gene also influences responsiveness to this antigen; it it closely linked to the H-17 locus which has not yet been assigned to a specific chromosome. Genes on chromosomes 1,4, and 5 were found to influence the magnitude of the antibody response to dextran B-1355. Some of these genes appear to be antigen-specific in their mode of action; however, others are not since they exert an influence on the antibody response to both SSS-III and dextran B-1355.