Understanding how dynamic changes in chromatin composition control genome function

DNA在真核细胞中以染色质的形式紧密包装。重要的遗传过程，如转录，需要操纵染色质结构以访问DNA。细胞建立专门的染色质结构来调节这些过程。目前，这些特殊结构的精确分子细节是有限的。这个项目将推动体外模型染色质系统的信封，并确定几个染色质状态的结构与独特的功能在细胞内的影响。这将解开定义我们基因组如何组织的分子指令，大大推进我们对基础真核基因组生物学的了解，并为未来开发新工具和疗法铺平道路。

DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and determine the architecture of several chromatin states with unique functional implications inside the cell. This will unravel the molecular instructions that define how our genomes are organised, significantly advancing our knowledge of fundamental eukaryotic genome biology and paving the way for the future development of new tools and therapies.