Mechanistic models in occupational cancer epidemiology

描述(由申请人提供)：该项目的目标是为理查森博士提供必要的培训和有指导的研究经验，使他能够从事生物学癌症模型领域的研究，并对此做出重大贡献。该项目包括课程作业、指导学习和指导研究体验的阶段。这项研究项目汇集了美国癌症生物学、流行病学和生物统计学方面的一些专家，为培训理查森博士在职业研究中开发和应用基于生物的致癌模型的总体目标做出了贡献。使用这种模型需要的技能和培训与传统的统计流行病学分析所采用的有很大不同。开发和使用生物数学癌症模型需要了解当代对癌症生物学的理解。使用这些模型还需要了解它们的数学基础，这与用于队列分析的传统统计模型明显不同。最后，将这些模型用于职业研究需要一段时间的培训和有监督的研究，以便在开发和应用这些方法方面获得实际经验。加强癌症生物学和职业性癌症研究之间的联系已被国家职业研究议程小组确定为迫切需要。对理查森博士来说，生物数学模型的使用是一个新的研究领域；拟议中的这一研究领域的培训将使理查森博士能够为将癌症生物学纳入最先进的职业癌症流行病学研究方法做出贡献。理查森博士的目标是发展这些方法的专业知识，目标是以实际的方式应用这些方法，以解决职业安全和健康问题。人们的期望是，利用关于致癌生物过程的知识将提高识别和理解职业致癌物影响的能力。

DESCRIPTION (provided by applicant): The objective of this project is to provide Dr. Richardson with the training and supervised research experience necessary for him to engage in, and substantially contribute to, research in the area of biologically-based cancer models. The project includes periods of coursework, guided study, and supervised research experience. This research project draws together some of the nation's experts in cancer biology, epidemiology, and biostatistics to contribute to the overall goal of training Dr. Richardson in the development and application of biologically-based models of carcinogenesis for occupational research. The use of such models requires substantially different skills and training from those employed in traditional statistical epidemiological analyses. The development and use of biomathematical cancer models requires an understanding of contemporary understanding of cancer biology. The use of such models also requires understanding of their mathematical foundations, which are markedly different from traditional statistical models for cohort analyses. Finally, use of such models for occupational research purposes requires a period of training and supervised research in order to gain practical experience in the development and application of these methods. Strengthening the linkage between cancer biology and occupational cancer research has been identified as a critical need by the National Occupational Research Agenda Team. The use of biomathematical models is a new research area for Dr. Richardson; the proposed training in this research area will allow Dr. Richardson to make a contribution to the incorporation of cancer biology into state-of-the-art occupational cancer epidemiology research methods. Dr. Richardson's objective is to develop expertise in these methods with the goal of applying them in practical ways to address occupational safety and health concerns. The expectation is that use of knowledge about biological processes of carcinogenesis will improve the ability to identify and understand the effects of occupational carcinogens.