Keystone Symposium on Cell Death in the Immune System

摘要 这项提案是为了请求支持一个名为免疫系统中的细胞死亡的Keystone研讨会会议。 系统由道格拉斯R.绿色和帕姆S.大桥，这将在布雷肯里奇，科罗拉多举行 从2008年2月7日至12日。体内有两个过程，其中单个细胞的生或死可以 对个人的健康产生深远的影响。一个是，当然，癌症。另一种是免疫者 一种特定淋巴细胞的后代可以介导的免疫应答。本次会议将重点讨论 在免疫反应中控制细胞死亡和存活的分子机制，以及这些过程如何 影响免疫结果。该领域的前沿课题包括半胱天冬酶的调节及其控制 凋亡细胞及其相关抗原的清除和对免疫反应的影响 反应，细胞毒性机制，包括新的颗粒酶和死亡受体，以及自噬的作用 所有这些都将在这次会议上讨论。与题为“细胞”的基石专题讨论会的联席会议 死亡和细胞衰老，将集中在细胞凋亡的一般机制，包括Bcl-2家族， 细胞内稳态和细胞存活中的信号事件。

ABSTRACT This proposal is to request support for a Keystone Symposia meeting entitled ¿Cell Death in the Immune System¿, organized by Douglas R. Green and Pam S. Ohashi, which will be held in Breckenridge, Colorado from February 7 ¿ 12, 2008. There are two processes in the body in which the life or death of a single cell can profoundly impact on the health of the individual. One is, of course, cancer. The other is the immune response which can be mediated by the progeny of one specific lymphocyte. This meeting will focus on the molecular mechanisms controlling cell death and survival during immune responses, and how these processes affect immune outcome. Topics at the forefront of this field include the regulation of caspases and their control of inflammatory events, the clearance and impact of apoptotic cells and their associated antigens on immune responses, cytotoxic mechanisms including novel granzymes and death receptors, and the role of autophagy in host defense, all to be addressed in this meeting. Joint sessions, with the Keystone Symposium entitled Cell Death and Cellular Senescence, will focus on general mechanisms of apoptosis, including the Bcl-2 family, cellular homeostasis, and signaling events in cell survival.