NATIONAL NEUROLOGICAL AIDS BANK

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 国家神经系统艾滋病库（NNAB）这项R24赠款的主要目标是提供来自晚期艾滋病受试者和血清阴性对照受试者的特征良好的人体组织、体液和医学数据。招募受试者并在其生命期间进行纵向随访，进行标准化和质量控制的检查，包括神经医学检查、神经心理学测试、精神/药物滥用/毒理学测试、血液、尿液和CSF采集，每6个月一次。根据AAN标准，采用疑名法进行了一系列神经医学诊断。受试者在死前同意在死后进行快速尸检。遵循标准化的神经病理学方案来切割、制备和储存组织，并建立一系列标准化的神经病理学诊断。类似地制备全身组织。合格的研究人员可以免费获得死后液体、福尔马林固定和冷冻组织（运输除外），他们将方案提交给我们的指导委员会进行审查。虽然不是原始RFA的一部分，但NNAB已经在丙型肝炎合并感染、临床研究和神经影像学领域建立了几个附加方案，我们期待充分利用这一队列。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this R24 grant, National Neurological AIDS Bank (NNAB), is to provide well-characterized human tissue, fluids, and medical data from subjects with advanced AIDS and seronegative comparison subjects with other diseases. Subjects are recruited and followed longitudinally during life, with standardized and quality-controlled examinations that include a neuromedical examination, neuropsychological testing, psychiatric/substance abuse/toxicological testing, blood, urine, and CSF collection every 6 months. An algorthymic approach is followed to achive a series of neuromedical diagnoses based on the AAN criteria. Subjects give pre-mortem consent to a rapid autopsy after death. A standardized neuropathological protocol is followed to cut, prepare, and store tissue, and to establish a series of standardized neuropathological diagnoses. Systemic tissue is prepared similarly. Post-mortem fluids, formalin-fixed, and frozen tissue is available at no cost (except for shipping) to qualified researchers who submit protocols for review to our Steering Committee. Although not a part of the original RFA, NNAB has established several add-on protocols in the area of Hepatitis C co-infection, clinical studies, and neuroimaging to the original protocol, and we look forward to taking full advantage of this cohort.