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Cutaneous Adverse Drug Reactions

Cutaneous Adverse Drug Reactions
皮肤药物不良反应
批准号：
7965853
负责人：
Heidi Kong
金额：
$4.21万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7965853
关键词：
Adverse effectsAppearanceBAY 54-9085BiopsyClassificationClinicClinicalClinical TrialsCollaborationsConsultCutaneousDataDermatologicDermatologistDermatologyDiagnosisDoseDrug toxicityEvaluationGoalsHandKnowledgeLifeMediatingMedicalNational Cancer InstituteOncologistPainPalmar-plantar erythrodysesthesia syndromePathogenesisPatientsPharmaceutical PreparationsPhotographyProtocols documentationPublishingReactionRecording of previous eventsResearchRisk FactorsSkinTherapeuticTimeUnited States National Institutes of Healthbaseexperiencefootimprovedmedical specialtiesnoveloncologyresearch clinical testing

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中文摘要
翻译
在2009财年，我们公布了三项NCI内部试验中与索拉非尼治疗相关的手足皮肤反应的数据，以更好地了解这种痛苦治疗的潜在风险因素和可能的发病机制-限制皮肤不良反应。这项研究需要皮肤科医生、肿瘤学家、药剂学家和统计学家之间的多专业合作。在基线和治疗期间，正在对使用其他研究疗法的患者进行皮肤病学系统评估。除了彻底的临床评估外，受试者还可以接受皮肤活检和医学摄影。
英文摘要
In fiscal year 2009, we published the data on hand-foot skin reaction related to sorafenib therapy from three NCI intramural trials to better understand the potential risk factors and possible pathogenesis of this painful treatment-limiting cutaneous adverse effect. This research required multi-specialty collaboration among dermatologists, oncologists, pharmacologists and statisticians. Patients on other investigational therapeutics are being systematically evaluated dermatologically at baseline and while on treatment. In addition to thorough clinical evaluations, subjects may undergo skin biopsies and medical photography.
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Effects of systemic and topical perturbations on human microbes
Botulinum Toxin for Painful Cutaneous Leiomyomas
Gene Expression Profiling and Clinical Characterization of Phototoxicity
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients
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