IVIS Spectrum Imaging System for the University of South Carolina

描述（由申请人提供）：本提案要求为南卡罗来纳州大学购买Caliper LifeSciences IVIS Spectrum体内成像系统，金额为381，491美元。IVIS Spectrum是一种最先进的仪器，将满足南卡罗来纳州大学生物医学研究界未来几年的体内荧光和生物发光成像需求。该系统将实现体内生物光子成像，用于非侵入性和纵向监测本提案所有研究人员使用的小鼠和大鼠模型中的疾病过程、细胞反应和遗传途径。南卡罗来纳州大学没有用于荧光和生物发光成像的体内成像系统。该提案的调查人员是10名资金充足的科学家，他们代表了南卡罗来纳州大学的大型生物医学研究团体，将从IVIS光谱体内成像系统的收购中受益。作为一个小组，研究人员是P20结肠癌研究中心COBRE，P01自身免疫和炎症性疾病CAM研究中心，11 R01赠款，美国心脏协会科学家发展赠款和美国癌症协会研究学者赠款的主要研究者。他们也是代表艺术和科学，公共卫生，药学和医学学院的高级和初级研究人员的混合。此外，Price博士和佩纳博士是中心赠款的核心PI，与南卡罗来纳州的大量研究人员互动，这项技术将提供给所有参与这些生物医学研究项目的研究人员。该系统将安置在南卡罗来纳州大学医学院的仪器资源设施中。国际研究基金会是一个已建立的核心生物技术设施，为南卡罗来纳州大学以及南卡罗来纳州的其他几个本科和研究生院提供服务。 公共卫生相关性：随着时间的推移，活体动物的非侵入性成像已成为监测许多疾病（包括癌症、炎症反应和心血管疾病）进展的重要研究工具。本提案中要求的IVIS光谱荧光和生物发光技术将成为南卡罗来纳州大学生物医学研究人员在这些领域开发转化研究计划以及开发新药和治疗方案的重要工具。

DESCRIPTION (provided by applicant): This proposal requests $381,491 for the purchase of a Caliper LifeSciences IVIS Spectrum in vivo imaging system for the University of South Carolina. The IVIS Spectrum is a state-of-the-art instrument that will meet the in vivo fluorescence and bioluminescence imaging needs of the University of South Carolina biomedical research community for the next several years. The system will enable in vivo biophotonic imaging for the purpose of non-invasively and longitudinally monitoring disease processes, cellular responses and genetic pathways in mouse and rat models used by all of the investigators on this proposal. There are no in vivo imaging systems for fluorescence and bioluminescence imaging at the University of South Carolina. Investigators on this proposal are ten well funded scientists representative of the larger biomedical research community at the University of South Carolina that will benefit from acquisition of the IVIS Spectrum in vivo imaging system. As a group the investigators are Principle Investigators of a P20 Center for Colon Cancer Research COBRE, a P01 Center for CAM Research on Autoimmune and Inflammatory Diseases, 11 R01 grants, an American Heart Association Scientist Development grant, and an American Cancer Society Research Scholar Grant. They are also a mix of senior and junior investigators that represent the Colleges of Arts and Sciences, Public Health, Pharmacy, and Medicine. In addition, Drs. Price and Pena are PIs of Cores for Center grants that interact with a large number of investigators around the state of South Carolina and this technology will be made available to all investigators involved with these biomedical research programs. The system will be housed in the Instrumentation Resource Facility of the University Of South Carolina School Of Medicine. The IRF is an established core biotechnology facility serving the University of South Carolina as well as several other undergraduate and graduate institutions in the State of South Carolina. PUBLIC HEALTH RELEVANCE: Non-invasive imaging of living animals over time has become an important research tool in monitoring the progression of a number of diseases including cancer, inflammatory responses, and cardiovascular disease. The IVIS Spectrum fluorescence and bioluminescence technology requested in this proposal will be an important tool for biomedical researchers at the University of South Carolina in their efforts to develop translational research programs in these areas as well as in development of new drugs and treatment regimens.