OBESE NONHUMAN PRIMATE RESOURCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肥胖是发达国家面临的主要健康挑战之一，极大地增加了患冠心病和糖尿病的风险。最近有研究表明，一个人的身体质量指数(BMI)每超过25个“点”，患心脏病的风险就会相应增加。据估计，美国医疗保健支出的9.4%与“肥胖和缺乏运动”直接相关，而最近因糖尿病造成的成本估计为每年980亿美元。要成功地了解代谢性疾病危机的原因、后果和可能的解决方案，就需要对该问题进行全方位的基础、翻译和临床研究和流行病学研究。为了开发一种研究这种疾病的模型，我们小组选择了高脂饮食诱导肥胖(DIO)NHP模型。DIO-NHP是少数几个能全面发展代谢综合征的模型之一，包括肥胖、胰岛素抵抗、糖尿病、心血管疾病(高血压和动脉粥样硬化)和免疫功能障碍。此外，NHP具有与胰岛相似的细胞结构，代谢系统的发育个体发育与人类相似。所有这些都使NHP成为研究人类代谢性疾病最合适的模型。此资源的目的是让研究人员能够访问具有广泛特征的DIO猕猴模型，而不必自己承担全部费用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is one of the major health challenges facing the developed world, significantly increasing the risk of coronary disease, and of diabetes. It has recently been shown that for every "point" by which a person's body mass index (BMI) exceeds 25, there is an associated increase in the risk of cardiac disease. An estimated 9.4% of US healthcare expenditure is directly related to "obesity and inactivity", while recent costs due to diabetes were estimated at $98 billion per annum. A successful understanding of the causes, consequences, and possible solutions to the metabolic disease crisis will require that the full spectrum of basic, translational, and clinical research and epidemiology be brought to bear on the problem. To develop a model to study this disease our group has chosen to use the high fat diet induced obese (DIO) NHP model. The DIO-NHP is one of the few models that develops the full spectrum of the metabolic syndrome, including, obesity, insulin resistance, diabetes, cardiovascular diseases (hypertension and atherosclerosis), and immune dysfunction. Furthermore, the NHP has a similar cyto-architecture of the pancreatic islets and the developmental ontogeny of metabolic systems is similar to humans. All of these points make the NHP the most appropriate model for the human metabolic diseases. The purpose of this resource is to provide investigators access to the extensively characterized DIO macaque model, without having to incur the whole expense themselves.