Lung Development and Repair

描述(由申请人提供)：本提案请求支持由Brigid L.M.Hogan、Ross Metzger和Edward E.Morrisey组织的题为肺发育和修复的Keystone研讨会，该会议将于2011年2月6-11日在新墨西哥州圣达菲举行。肺是一个复杂的三维器官。它的重要功能依赖于多种组织类型之间动态相互作用的初始建立和维持。其中包括高度分枝的呼吸道导管和终末肺泡囊系统、血管和淋巴管、神经、平滑肌和成纤维细胞以及免疫系统的细胞。这些相互作用的缺陷导致了许多严重的呼吸系统疾病，无论是在新生儿还是成年人。关于肺发育和修复的Keystone研讨会会议将重点介绍我们在理解推动肺发育的分子和细胞过程、如何在成人中长期保持其组织以及这些机制如何在疾病中受到干扰方面的最新进展。新的想法和方法将被来自其他器官系统的例子所催化。会议还将讨论肺部生物学的一个主要目标：确定在受到环境因素或疾病损害后，介导组织再生和修复的祖细胞。 公共卫生相关性：在西方世界，肺部疾病是导致发病率和死亡率的主要原因之一。鉴于其高的临床负担，对肺发育、修复和再生的基本机制的进一步研究将为新生儿和成人肺部疾病提供重要的见解。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Lung Development and Repair, organized by Brigid L.M. Hogan, Ross Metzger and Edward E. Morrisey, which will be held in Santa Fe, New Mexico from February 6 - 11, 2011. The lung is a complex three-dimensional organ. Its vital functions depend upon the initial establishment and maintenance of dynamic interactions between multiple tissue types. These include the highly branched system of airway tubes and terminal alveolar sacs, blood and lymphatic vessels, nerves, smooth muscle and fibroblasts, and cells of the immune system. Defects in these interactions underlie many serious respiratory disorders, both in the neonate and adult. The Keystone Symposia meeting on Lung Development and Repair will highlight recent advances in our understanding of the molecular and cellular processes driving the development of the lung and how its organization is maintained over the long term in the adult, as well as how these mechanisms are perturbed in disease. New ideas and approaches will be catalyzed by examples from other organ systems. The meeting will also address a major goal in lung biology: to identify the progenitor cells that mediate tissue regeneration and repair after damage by environmental factors or disease. PUBLIC HEALTH RELEVANCE: Pulmonary disease is one of the leading causes of morbidity and mortality in the Western world. Given its high clinical burden, additional investigation into the basic mechanisms underlying lung development, repair, and regeneration will provide important insight into neonatal and adult lung disease.