VISUAL PROCESSING AND SMOOTH EYE MOVEMENTS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本研究的目的是探讨早期视觉经验在凝视、眼球对准和眼球运动(顺畅追赶)发展中的作用。特别强调的是皮层和相关的脑干神经元对斜视猕猴的凝视和眼球运动至关重要。目标是确定导致眼球运动障碍的神经底物，如潜伏性眼球震颤、不对称平滑追踪和与贫乏的双眼视觉体验相关的斜视。我们已经开发了有效的斜视猕猴模型，它提供了对与婴儿斜视相关的神经关联的洞察，可能会导致改善诊断和治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this research project is to consider the role of early visual experience in development of gaze-holding, eye alignment and ocular motility (smooth pursuit). Special emphasis is devoted to cortical and associated brainstem neurons essential for gaze-holding and eye movements of strabismic macaques. The goal is to determine the neural substrate responsible for eye movement disorders such as latent nystagmus, asymmetric smooth pursuit and strabismus associated with impoverished binocular visual experience. We have developed effective macaque models for strabismus, which provide insight into neural correlates related to infantile strabismus that could lead to improved diagnosis and treatments.