DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们正在开发基于Delta-P1和高阶扩散的模型，以便在更广泛的临床情况下准确处理FDPM数据。具体地说，正在进行FDPM测量以探测分层组织结构以及评估小组织体积的属性。在这两种应用中，我们都要求在小源-探测器(S-D)间隔下进行FDPM测量。这些基于增量-P1和高阶扩散的模式适应了空间分布的准直源，并在小的S-d分离和广泛的反照率范围内提供了准确的预测。我们将把这些结果与使用标准扩散近似和实验得出的解进行比较。我们还将求解稳定的和幅度调制的准直光源照亮无限大介质表面的新方程。将结果与SODT和实验结果进行比较。我们目前正在研究用这个理论模型来解决诗歌中S-d的小分离问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are developing the delta-P1 and higher order diffusion based models to allow accurate processing of FDPM data in a broader number of clinical situations. Specifically, are making FDPM measurements to probe layered tissue structures as well as assess the properties of small tissue volumes. In both these applications, we require FDPM measurements to be made at small source-detector (S-D) separations. These delta-P1 and higher order diffusion based models accommodate spatially distributed collimated sources and provide accurate predictions at small s-d separations and over a broad range of albedo. We will compare these results to solutions derived using the standard diffusion approximation and experiment. We will also solve the new equations for steady and amplitude modulated collimated sources illuminating the surface of an infinite medium. Compare results with SODT and experiment. We are currently investigating the use of this theoretical models to solve th e in verse problem at small s-d separations.