Chemokines and Leukocyte Trafficking in Homeostasis and Inflammation

描述（由申请人提供）：本提案要求支持由William a . Agace， Sirpa Jalkanen和Sergio a . Lira组织的题为“趋化因子和白细胞在稳态和炎症中的运输”的Keystone专题会议，该会议将于2012年1月8日至13日在科罗拉多州的Breckenridge举行。白细胞亚群有组织地通过身体的组织区室进行贩运，对于产生先天和适应性免疫反应以及正常器官免疫监测至关重要；然而，当被误导时，这样的过程可以促进不受控制的炎症导致组织病理。现在已经确定细胞粘附和趋化因子受体在调节组织特异性白细胞迁移中起核心作用。最近的研究已经开始揭示这些受体在淋巴细胞上表达的复杂机制，并强调了局部淋巴结环境和迁移树突状细胞在诱导外周组织归巢受体中的重要性。虽然免疫学家传统上倾向于关注原发性和继发性淋巴细胞室来研究免疫过程和免疫细胞的相互作用，但越来越多的人认识到，我们的许多免疫细胞（如果不是大多数的话）位于外周组织，并且每个部位都具有独特的免疫特征。关于体内平衡和炎症中的趋化因子和白细胞运输的Keystone专题会议将汇集具有免疫细胞迁移，细胞粘附/趋化因子受体调节和组织特异性白细胞运输方面专业知识的科学家和临床医生，重点关注健康和疾病中的外周组织区室。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Chemokines and Leukocyte Trafficking in Homeostasis and Inflammation, organized by William A. Agace, Sirpa Jalkanen and Sergio A. Lira, which will be held in Breckenridge, Colorado from January 8 - 13, 2012. The organized trafficking of leukocyte subsets through the tissue compartments of the body is critical to the generation of innate and adaptive immune responses and for normal organ immuno-surveillance; however, when misguided, such processes can promote uncontrolled inflammation resulting in tissue pathology. It is now well established that cellular adhesion and chemokine receptors play a central role in regulating tissue-specific leukocyte migration. Recent studies have started to unravel the complex mechanisms underlying the expression of these receptors on lymphocytes and highlight the importance of the local lymph node environments and migratory dendritic cells in the induction of peripheral tissue homing receptors. While immunologists have traditionally tended to focus on primary and secondary lymphoid compartments to study immunological processes and immune cell interactions, there is a growing realization that many, if not most, of our immune cells are located in peripheral tissues and that each of these sites possess unique immunological characteristics. The Keystone Symposia meeting on Chemokines and Leukocyte Trafficking in Homeostasis and Inflammation will bring together scientists and clinicians with expertise in immune cell migration, cellular adhesion/chemokine receptor regulation and tissue specific leukocyte trafficking with a focus on the peripheral tissue compartments in health and disease. PUBLIC HEALTH RELEVANCE: Leukocytes - white blood cells - have a chief function of protecting the body against microorganisms that cause disease. The organized trafficking of leukocyte subsets through the tissue compartments of the body is critical to the generation of immune responses and for normal organ immuno-surveillance; however, when misguided, such processes can promote uncontrolled inflammation and result in disease. The overall aim of the Keystone Symposia meeting on Chemokines and Leukocyte Trafficking in Homeostasis and Inflammation is to highlight the importance of tissue and micro-environmental context in the regulation of immune cell trafficking, with a particular focus on peripheral tissue compartments and the underlying mechanisms regulating the specificity of lymphocyte homing.