Hematopoiesis

描述（由申请人提供）：请求支持由伦纳德I组织的题为造血的基石研讨会会议。Zon，Stuart H.作者声明：A.斯派克，将于2013年1月14日至19日在科罗拉多的汽船泉举行。造血是造血干细胞自我更新和分化形成外周血谱系的过程。本次会议旨在从自我更新过程、造血系统的发展和分化方面对这一过程形成一个广泛的观点。全体会议将包括造血干细胞的诞生，一直到整个成年期成熟细胞谱系的发展。他们将包括关于发育造血的会议，将探讨胚胎中血液系统的诞生，关于成人干细胞自我更新的会议，以及关于干细胞利基和新型造血调节剂的会议。特别令人兴奋的研究领域，将在会议上包括识别新的生长因子，增强干细胞的决策，在我们的理解的转录机制，使用新的遗传和基因组技术的进步，和新的表观遗传机制，调节白血病干细胞群体。会议还将讨论正在为临床试验开发的药物策略。总之，我们预计这次会议将产生新的见解的生物学和潜在的治疗用途的造血干细胞及其后代的控制癌症和疾病。公共卫生相关性：造血是造血干细胞-产生所有血细胞类型的细胞-自我更新和分化为外周血谱系的过程。在美国，每年有近10，000例死亡直接归因于血液相关疾病，血液和血液形成系统的功能障碍是美国死亡的主要原因，包括心血管疾病、癌症、糖尿病和中风。Keystone Symposia造血会议将聚集国际公认的研究人员，他们致力于血细胞发育，恶性肿瘤和贫血，根据新出现的数据开发新的假设。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Hematopoiesis, organized by Leonard I. Zon, Stuart H. Orkin and Nancy A. Speck, which will be held in Steamboat Springs, Colorado from January 14 - 19, 2013. Hematopoiesis is the process by which hematopoietic stem cells self-renew and differentiate to form the peripheral blood lineages. This meeting seeks to develop a broad view of this process in terms of the self- renewal process, development of the hematopoietic system, and differentiation. Plenary sessions will encompass the birth of hematopoietic stem cells all the way through development of mature cell lineages throughout adult life. They will include sessions on developmental hematopoiesis that will explore the birth of the blood system in embryos, sessions on adult stem cell self-renewal, and sessions on stem cell niches and novel hematopoietic regulators. Particularly exciting areas of research that will be covered in the meeting include the identification of new growth factors that enhance stem cell decisions, advances in our understanding of transcription mechanisms using new genetic and genomic technologies, and new epigenetic mechanisms that regulate leukemic stem cell populations. The meeting will also address drug strategies that are being developed for clinical trials. Taken together, we anticipate that this conference will yield novel insights into the biology and potentil therapeutic uses of hematopoietic stem cells and their progeny for the control of cancer and disease. PUBLIC HEALTH RELEVANCE: Hematopoiesis is the process by which hematopoietic stem cells - the cells that give rise to all blood cell types - self-renew and differentiate to for the peripheral blood lineages. In the United States, nearly 10,000 deaths annually are directly attributable to blood-related diseases, and dysfunction of the blood and blood-forming system contributes too many of the leading causes of death in the U.S., including cardiovascular disease, cancer, diabetes and stroke. The Keystone Symposia meeting on Hematopoiesis will gather internationally recognized investigators who work on blood cell development, malignancy, and anemias to develop new hypotheses based on emerging data.