The Innate Immune Response in the Pathogenesis of Infectious Disease

描述（由申请人提供）：请求支持由Ricardo T. Gazzineli，Gustavo P. Amarante-Mendes，Anne O'Garra and Alan Sher.会议将于2013年5月10日至15日在巴西米纳斯吉拉斯的欧罗普雷托举行。本次会议的一般主题是高度相关的NIAID使命方面的先天免疫和免疫系统在健康和疾病中的作用。有效治疗或预防传染病的免疫干预措施的合理发展仍处于起步阶段。几十年来，大多数关于免疫发病机制的研究都涉及主要由淋巴细胞介导的物理损伤和炎症。本次Keystone研讨会会议的主要焦点将是先天免疫系统和微生物病原体的界面，以及它在保护性免疫反应和有害免疫反应中所起的作用，从而影响疾病的结局。该计划将促进对基本概念的讨论，以及先天免疫在宿主抵抗力和传染病发病机制中的作用的新进展，特别强调热带地区的感染。来自不同领域的研究人员，如生物化学，细胞生物学，免疫学，微生物学，寄生虫学，传染病，热带医学和生物技术将包括在内，以鼓励跨学科的概念和该领域的新方向的讨论。这是将在巴西举行的一系列Keystone专题讨论会的第一次会议，还应促进拉丁美洲学生和科学家的参与。这些与会者与该领域主要国际专家的密切互动应能产生一种令人振奋的气氛，我们希望这种气氛将促进新的南北合作和研究网络的发展。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled The Innate Immune Response in the Pathogenesis of Infectious Disease, organized by Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher. The meeting will be held in Ouro Preto, Minas Gerais Brazil from May 10 - 15, 2013. The general topic of this meeting is highly relevant to the NIAID mission with respect to innate immunity and the role of the immune system in health and disease. The rational development of immunological interventions that are effective for treating or preventing infectious diseases is still on its infancy. For decades, the majority of the studies on immunopathogenesis have dealt with physical damage and inflammation, primarily mediated by lymphocytes. The main focus of this Keystone Symposia meeting will be on the interface of the innate immune system and microbial pathogens and the role that it plays in protective versus deleterious immune responses and, thereby, of disease outcome. The program will promote discussions on fundamental concepts as well as new advances in the role of innate immunity in host resistance and pathogenesis of infectious diseases, with special emphasis on infections of the tropics. Investigators from different areas, such as biochemistry, cell biology, immunology, microbiology, parasitology, infectious diseases, tropical medicine and biotechnology will be included to encourage the discussion of interdisciplinary concepts and new directions for the field. This is the first of a series of Keystone Symposia meetings to be held in Brazil, and should also foster the participation of Latin American students and scientists. The close interaction of these participants with leading international experts in the field should lead to a stimulating atmosphere that we hope will promote the development of new South-North collaborations and research networks.