Expansion & Improvement of Nonhuman Primate Caging at the WaNPRC

摘要 华盛顿国家灵长类动物研究中心（WaNPRC）提供基础设施和研究支持 大量的生物医学研究项目利用非人灵长类动物（NHP）作为人类的模型， 疾病目前的住房准则、条例和标准要求研究设施提供社会服务， 为所有国家卫生保健中心提供住房，除非有科学或兽医豁免。许多研究方案， WaNPRC允许社会住房，其他人允许社会互动，至少在研究的一部分 而不影响实验结果。由于以下几个因素，NHP的社会化可能具有挑战性 和设施限制。为了应对这些挑战，我们设计了一个创新的模块化笼系统 这是灵活的，足以促进社会的NHP安置在中心。然而， 这些新的模块化笼子的数量，以提供社会住房的动物目前正在研究，并为我们的 融资设施扩建。因此，本建议寻求支持，以购买额外的笼，以符合 新的要求。新的NHP笼将取代老式笼，并为我们的 我们的西部设施和拟议的ARC大楼的预定翻新。为了增加我们的持股 由于我们需要增加笼舍的容量及遵守规例，我们需要购买很多新笼舍。这笔赠款将允许 购买50个模块式不锈钢灵长类动物富集装置（100个笼子）。该提案特别要求 购买27个第3组机架单元（54个笼）和23个第4组机架单元（46个笼）。资金来源于此 这项提议将大大提高我们为关键的生物医学研究提供更多猕猴的能力。 研究项目。

ABSTRACT The Washington National Primate Research Center (WaNPRC) provides infrastructure and research support for a large number of biomedical research projects utilizing nonhuman primates (NHP) as models for human disease. Current housing guidelines, regulations and standards require that research facilities provide social housing for all NHPs unless there are scientific or veterinary exemptions. Many of the research protocols at the WaNPRC allow for social housing and others allow for social interactions at least for a portion of the study without compromising experimental outcomes. Socialization of NHP can be challenging due to several factors and facility constraints. To address the challenges, we have designed an innovative modular caging system that is flexible enough to facilitate socialization of NHP housed at the center. However, there are insufficient numbers of these new modular cages to provide social housing for animals currently on study and for our funded facility expansions. Therefore, this proposal seeks support to purchase additional caging to comply with the new requirements. The new NHP caging will replace old-style cages and provide additional cages for our scheduled renovation of our Western facility and the proposed ARC building. In order to increase our holding capacity and compliance with regulation, we need to purchase many new cages. This grant would allow is to purchase 50 modular stainless steel primate enrichment units (100 cages). The proposal specifically requests the purchase of 27 Group 3 rack units (54 cages) and 23 Group 4 rack units (46 cages). Funding from this proposal would greatly enhance our ability to socially house additional macaques for critical biomedical research projects.