B Cell Renaissance: Epigenetics, Regulation and Immunotherapy

摘要 请求为题为“B细胞复兴：表观遗传学”的Keystone专题讨论会提供支助， 调节和免疫疗法，由Paolo Casali博士，Nicole Baumgarth，Meinrad Busslinger和 伊丽莎白·利百特会议将于2019年3月1日至5日在加拿大阿尔伯塔班夫举行。 本次会议将汇集专家在B细胞生物学讨论的最新进展，B细胞 研究从最初的发展，通过成熟，包括效应或记忆的发展，直到终端 分化这些最近的B细胞研究的结果正在指导研究人员变得更加欣赏 分子变化的重要性，包括表观遗传标记，修饰和控制因素， 并调节B细胞发育和分化以及影响功能的调节力 B细胞的途径。B细胞分化途径的复杂性，通过生发中心和外 初级淋巴器官中的滤泡灶，以及不同次级淋巴器官中的新相互作用， 组织，也在小鼠和人类中进行深入研究。B细胞与淋巴细胞的相互作用， 非淋巴样细胞和分泌因子在无数的环境将涵盖在会议会议。 这将有助于阐明影响并最终决定每一个人的贡献的众多因素。 独特的B细胞亚群对体内平衡、免疫防御或免疫病理学的作用。了解驱动因素， 影响B细胞分化和功能将使得能够精确地利用这些关键要素来优化 B细胞及其抗体在自身免疫性疾病、感染和癌症中的免疫治疗作用。

ABSTRACT Support is requested for a Keystone Symposia conference entitled B Cell Renaissance: Epigenetics, Regulation and Immunotherapy, organized by Drs. Paolo Casali, Nicole Baumgarth, Meinrad Busslinger and Elizabeth Leadbetter. The conference will be held in Banff, Alberta Canada from March 1-5, 2019. This conference will bring together experts in B cell biology to discuss the most recent advances in B cell research from initial development, through maturation, including effector or memory development, until terminal differentiation. The results of these recent B cells studies are guiding researchers to become more appreciative of the importance of the molecular changes, including epigenetic marks, modifications and factors that control and modulate B cell development and differentiation as well as the regulatory forces which influence functional paths of B cells. The complexities of B cell differentiation pathways through germinal centers and extra- follicular foci in primary lymphoid organs, in addition to novel interactions in diverse secondary lymphoid tissues, are also under intense study in both mice and humans. The interactions of B cells with lymphoid cells, non-lymphoid cells, and secreted factors in a myriad of environments will be covered in conference sessions. This will help elucidate the numerous factors which influence and ultimately dictate the contribution of each unique B cell subset to homeostasis, immune defense or immunopathology. Understanding the drivers which influence B cell differentiation and function will enable precise harnessing of these key elements to optimize the immuno-therapeutic effect of B cells and their antibodies in autoimmune disease, infection, and cancer.