Transforming Vaccinology

摘要 要求为题为“转变疫苗学”的Keystone专题讨论会提供支助， Drs.放大图片作者：Lynda M.斯图尔特和费德里卡·萨卢斯托。会议将于2015年10月21日至22日在意大利的佛罗伦萨举行。 2020年3月15日至19日。 沿着清洁的水和抗生素，疫苗接种使人类战胜了传染病 这曾导致50%的儿童死亡在上个世纪，疫苗接种也延长了寿命 预期寿命从50岁以下到80岁以上。现在最重要的婴儿疫苗和 疫苗接种面临着新的挑战，目的是将疫苗的好处带给儿童， 其他年龄组、新出现的感染、抗菌素耐药性、困扰低收入国家的疾病，以及 改善慢性传染病、癌症、自身免疫和神经退行性疾病的治疗 疾病这种新疫苗的雄心得到了科学技术令人难以置信的进步的支持， 使针对许多新目标的疫苗开发在技术上成为可能，并通过创新方法， 为新出现的感染和低收入国家的疾病开发疫苗。的科技 正在改变疫苗学的是基于结构的设计，佐剂，核酸疫苗（特别是RNA）， 病毒载体、系统生物学和受控人类感染。它们得到了科学进步的支持， 人类免疫学、基因组学、合成生物学、抗原分子结构和抗原抗体 复合体、生发中心和微生物组。与会者将接触到多学科的 正在改变疫苗学的技术，包括CEPI，比尔和梅林达盖茨的努力 基金会和欢迎信托基金，以改变疫苗的开发方式。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Transforming Vaccinology, organized by Drs. Rino Rappuoli, Lynda M. Stuart and Federica Sallusto. The conference will be held in Florence, Italy from March 15-19, 2020. Along with clean water and antibiotics, vaccination has allowed mankind to conquer the infectious diseases that used to eradicate about 50% of children. Over the last century, vaccination has also extended life expectancy from under 50 to over 80 years of age. Now that the most important vaccines for infants and children are available, vaccination faces new challenges with the intent to bring the benefits of vaccines to other age groups, emerging infections, antimicrobial resistance, diseases that afflict low-income countries, and to improve therapies against chronic infectious diseases, cancer, autoimmune and neurodegenerative diseases. This new vaccine ambition is supported by the incredible advances in science and technology that make it technically possible to develop vaccines against many new targets and by innovative approaches to vaccine development for emerging infections and for diseases of low-income countries. The technologies that are transforming vaccinology are structure-based design, adjuvants, nucleic acid vaccines (especially RNA), viral vectors, systems biology, and controlled human infections. They are supported by scientific advances in human immunology, genomics, synthetic biology, molecular structure of antigens and antigen-antibody complexes, germinal centers, and microbiome. Conference participants will be exposed to the multidisciplinary technologies that are transforming vaccinology, including the efforts of CEPI, Bill and Melinda Gates Foundation and Welcome Trust, to change the way vaccines are developed.