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Investigating the microbiome in persons living with HIV

Investigating the microbiome in persons living with HIV
调查艾滋病毒感染者的微生物组
批准号：
10710341
负责人：
Heidi Kong
金额：
$26.38万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10710341
关键词：
ClinicalCollaborationsComplexData AnalysesDiseaseGoalsHIVHIV InfectionsHuman MicrobiomeImmune System DiseasesImmune systemImmunityIndividualInflammationInflammatoryMonitorOpportunistic InfectionsPersonsPredispositionResearch ProposalsSkinViral Load resultantiretroviral therapycomorbidityhost microbiotamicrobialmicrobiomemicrobiome sequencing

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中文摘要
翻译
我们建立了一个协作机制，对艾滋病毒感染者进行临床评估并收集生物标本。在一个横截面的方式，我们已经收集了生物标本，从个人开始抗逆转录病毒治疗之前，以及个人的抗逆转录病毒治疗。我们已经对生物标本进行了微生物组测序，并正在分析来自已开始抗逆转录病毒治疗的个人的数据，以便在免疫系统恢复和病毒载量得到控制时监测人体微生物组。
英文摘要
We have established a collaboration to clinically evaluate and collect biospecimens from persons living with HIV. In a cross-sectional manner, we have collected biospecimens from individuals prior to the initiation of antiretroviral therapy as well as individuals on antiretroviral therapy. We have performed microbiome sequencing of biospecimens and are analyzing data from individuals who have initiated antiretroviral therapy in order to monitor the human microbiome as the immune system is restored and as viral load is controlled.
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会议论文
Effects of systemic and topical perturbations on human microbes
Botulinum Toxin for Painful Cutaneous Leiomyomas
Gene Expression Profiling and Clinical Characterization of Phototoxicity
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients
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