SEARCH for Diabetes in Youth 2: Washington Site

这项建议建立在一个为期五年的研究项目，青年糖尿病，其标准化数据 收集工作，经验丰富的调查员团队，建立了病例确定基础设施， 多样的人口基础。这是一个来自六个临床试验机构的通用集成应用程序， 建议继续并扩大联合国难民事务高级专员办事处开展的工作，以解决以下具体问题： 研究目的：目的1：确定2006-2009年新发病例年龄小于 20年，以估计青年糖尿病发病率的时间趋势;目的2：进行纵向 * 对2002-2005年已被征聘到联合国调查科的事件案件采取后续行动，以记录 根据临床和生化因素新诊断的糖尿病;目的3：完整的分析开始在 第一个五年的评估，并扩大护理质量评估的范围，以更广泛地包括 定义的概念和质量度量;目标4：开发和验证简单和低成本的案例定义 和青年糖尿病类型的分类，可用于公共卫生监测。这件事的新奇之处在于 建议包括它的综合性质，汇集了儿童糖尿病的主要和及时的方面 研究：一项流行病学研究，在美国是独一无二的，研究了糖尿病发病率的时间趋势， 青年;解决青年DM自然史的病理生理学组成部分; 护理和生活质量;以及对青年糖尿病病例分类的公共卫生观点。的 华盛顿研究中心为SEARCH 1提供了大量多样的研究人群。凭借广泛的网络， 地方，包括研究人员和合作者，他们经常接触新的和持续的 参与者，WA网站可以有效地招募和跟踪案例。与WA的新合作 卫生署强调糖尿病监测和护理质量，并继续与 SEARCH 2与具有糖尿病研究和疾病演变专业知识的当地研究者一起， 非常积极的研究氛围和巨大的生产力。这项研究对公众至关重要。 健康，因为它将提供有关不同年龄段的青年人中DM是否增加以及增加多少的信息。 美国的种族/族裔群体，关于DM如何影响身体健康，包括 这些资料包括关于并发症的资料，以及关于这些青年的护理质量和生活质量的宝贵数据。

This proposal builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of DM in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. The Washington site contributed a large, diverse study population to SEARCH1. With an extensive network in place including investigators and collaborators who have regular contact with new and continuing participants, the WA site can efficiently recruit and follow cases. A new collaboration with the WA Department of Health emphasizing diabetes surveillance and quality of care, and continued collaboration in SEARCH2 with local investigators with expertise in diabetes research and evolution of disease will provide a very positive research atmosphere and great productivity. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ ethnic groups in the United States, about how DM impacts on the physical health, including complications, as well as valuable data regarding the quality of care and the quality of life of these youth.