ABNORMAL BEHAVIOR & ONSET OF INITIAL SOCIALIZATION AMONG RHESUS MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：苗圃饲养的猕猴的社会化通常包括大约一个月大时的初始社交暴露。然而，在生物医学环境中，社会化的开始可能会因为各种原因而推迟。这项正在进行的研究检验了一种预测，即这些延迟与社会寄居猕猴在发育和成熟过程中异常行为的广泛表达有关。方法：为了控制所经历的研究程序的类型和延迟社会化的原因，所有受试者都是从一个限制早期社会化的研究项目中抽取的。受试者包括35名女性和33名男性，这些人在1到54个月大的时候首次社交。每年对每个受试者进行三次五分钟的调查，记录16种异常行为的存在。每个主题的数据都收集了长达五年的时间。用回归程序评估社交年龄和异常行为频率之间的关系。结果：社会化起始年龄在生命的第2、3岁有显著影响，社会化起始年龄与异常行为的广度呈正相关。在生命的第四年，这种模式被观察到是一种趋势。结论：数据初步结果表明，关于早期社会化的决定需要在延迟社会化的理由和促进正常发展之间取得仔细的平衡。持续的研究将允许对许多现有的受试者在成熟后继续进行纵向检查，以衡量这些影响在大样本受试者中的持久性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: The socialization of nursery-reared macaques typically involves initial social exposure at approximately one month of age. However, in a biomedical environment, the onset of socialization may be delayed for a variety of reasons. This ongoing study examined the prediction that these delays are associated with broadened expression of abnormal behaviors among socially-housed rhesus macaques throughout development and maturation. Methods: In order to control for the types of research procedures experienced and the reason for delayed socialization, all subjects were drawn from one research project that imposed restrictions on early socialization. Subjects included 35 female and 33 males first socialized between one and 54 months of age. Three five-minute surveys were conducted on each subject annually, recording the presence of 16 abnormal behaviors. Data have been collected on each subject for up to five years. The association between age at socialization and frequency of abnormal behavior was assessed with regression procedures. Results: Significant effects of age at onset of socialization are apparent in the second and third year of life; onset of socialization was positively related to breadth of the abnormal behavior repertoire at these ages. This pattern was observed as a trend in the fourth year of life. Conclusion: Data Initial results suggest that decisions regarding early socialization need to strike a careful balance between the rationale for delayed socialization and the promotion of normal development. Continued research will permit continued longitudinal examination of many existing subjects as they mature into adults in order to measure the persistence of these effects among a large sample size of subjects.