STUDIES OF VISUAL PROCESSING & SMOOTH EYE MOVEMENTS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的研究旨在确定正常和病理性的平稳追踪眼球运动和凝视相关的视觉处理的神经基质。 我们正在努力定义早期视觉经验在眼动系统、眼动定位和凝视保持发展中的作用。 视觉和眼神经系统在出生时还不成熟。 如果早期的视觉体验受到损伤或先天性缺陷的影响，那么眼动障碍可能会随之而来，从而影响清晰的视觉。 在过去的一年里，我们取得了重大进展，证明背外侧脑桥核是必不可少的顺利追求适应。 我们还证明了与猴子实验性内斜视相关的鼻向平滑追踪偏差是由于视觉-视觉处理缺陷。 这是因为我们发现，虽然类似的意志性平滑追踪眼球运动是高度不对称的，但由前庭眼球反射产生的平滑眼球运动在内斜视事件中是对称的。我们目前的研究正在检查这种疾病的神经基质在MST，MT和额眼领域。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our studies are directed at defining the neural substrate for visual processing related to normal and pathological smooth pursuit eye movements and gaze-holding. We are working to define the role of early visual experience in the development of eye movement systems, eye alignment and gaze-holding. The visual and oculomotor systems are not mature at birth. If early visual experience is compromised by injury or congenital defect, eye movement disorders can follow that can compromise clear vision. During the last year we have made significant progress demonstrating that the dorsolateral pontine nucleus is essential for smooth pursuit adaptation. We have also demonstrated that the nasalward smooth pursuit bias associated with experimental esotropia in monkeys is due to a visual-oculomotor processing deficit. This is because we found that smooth eye movements generated by the vestibular ocular reflex were symmetric in esotropes event though comparable volitional smooth pursuit eye movements were highly asymmetric. Our current studies are examining the neuroal substrate for this disorder in areas MST, MT and frontal eye fields.