CLINICAL TRIAL: EFFECTS OF ANOREXIA NERVOSA ON PEAK BONE MASS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 患有神经性厌食症的青春期女孩患低骨密度的风险增加，到目前为止，还没有任何治疗方法在改善这一人群的骨量方面取得成功。我们正在招募12-18岁患有神经性厌食症的青春期女孩，以及相同年龄段的健康、正常体重的女孩，以确定服用低剂量雌激素是否会改善神经性厌食症的骨密度。这是一项为期18个月的双盲安慰剂对照研究，共对符合条件的受试者进行了4次住院治疗，因为其他7次研究访问可能是在麻省理工学院或当地进行的。这是四次可选的过夜检查，包括骨密度和激素评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent girls with anorexia nervosa are at increased risk for low bone density, and no treatment has thus far been documented as successful in improving bone mass in this population. We are recruiting adolescent girls with anorexia nervosa 12-18 years old, as well as healthy, normal weight girls of the same age range, to determine whether administration of low doses of estrogen leads to an improvement in bone density in anorexia nervosa. This is an 18-month long double blind placebo-controlled research study with a total of 4 hospital visits for qualifying subjects as the 7 other study visits may be comp leted either at MGH or locally. These are four optional overnight visits, which include bone density and hormonal evaluations.