Animal Holding Area Expansion in Support of AIDS-Related Research at the WaNPRC

华盛顿国家灵长类动物研究中心（WaNPRC）支持艾滋病相关研究项目已超过25年。这些项目是在西部设施进行的，那里的动物笼被设计为容纳非人类灵长类动物，其收容水平为ABSL-2，并为慢病毒研究实施了增强的收容措施。艾滋病相关研究项目正在扩大，增加了新的核心工作人员，为现有核心工作人员的新项目提供资金，并在核心工作人员与外部研究人员之间开展新的合作。由于预计动物数量将增加，需要升级笼子清洗设施，并需要为即将开展的项目扩大手术能力，华盛顿大学已承诺投入560万美元，将WaNPRC西部设施的动物饲养场扩大约2500平方英尺，安装新的笼子清洗/高压灭菌设备，并建造最先进的手术套件，以支持艾滋病相关研究。我们正在申请额外的资金，将目前的手术区改造成动物饲养区，并在扩大的动物饲养区内建造额外的动物饲养区。拟建的动物饲养室将容纳80只第四组（10-15公斤）非人灵长类动物，或更小的动物。这些房间将按照第八版《实验室动物护理和使用指南》的建议建造。动物饲养空间的建成将对机构资助的升级笼洗设施和手术室的项目起到协同作用，并将改善和提高我们进行生物医学研究的能力，特别是与艾滋病有关的研究。

The Washington National Primate Research Center (WaNPRC) has supported AIDS-related research projects for more than 25 years. These projects are performed at the Western facility, where the vivarium is designed to house nonhuman primates at an ABSL-2 containment level with enhanced containment practices implemented for lentivirus research. The AIDS-related research program is expanding with the addition of new core staff, funding of new projects for existing core staff, and new collaborative efforts between core staff and external investigators. With a projected increase in animal numbers, a need to upgrade cage wash facilities, and a need to expand surgical capabilities for upcoming projects, the University of Washington has committed $5.6 million to expand the vivarium by approximately 2500 square feet at the WaNPRC Western facility, install a new cage-wash/autoclave facility and build a state-of-the-art surgical suite for the support of AIDS-related research. We are requesting additional funding to convert the current surgical area into animal housing and to build out additional area within the expanded vivarium space for animal holding. The proposed animal holding rooms will accommodate 80 Group four (10-15 kg) nonhuman primates, or more smaller animals. The rooms will be constructed in accordance with the recommendations of the eighth edition of the Guide for the Care and Use of Laboratory Animals. The completion of the animal holding space will synergistically complement the institutionally-funded project to upgrade the cage-wash facilities and surgical suite, and will improve and increase our ability to conduct biomedical research, especially AIDS-related research.