LTQ Orbitrap Velos Mass Spectrometer System

描述（由申请人提供）：本提案要求使用Thermo Fisher Scientific LTQ Orbitrap Velos质谱仪系统，该系统将用于对人类健康具有重要意义的项目，例如：神经艾滋病、结核病、疟疾和其他传染病的发病机制;糖尿病和肥胖症、癌症;以及神经传递。所请求的仪器是下一代轨道阱仪器，其特点使其非常适合拟议的项目。这些项目强调定量蛋白质组学和翻译后修饰的研究。该仪器将在一个已建立的质谱资源实验室中使用，该实验室拥有高度互动环境中的高技能科学家。该仪器系统也将有利于最近资助的爱因斯坦NIDA蛋白质组学中心的神经艾滋病和药物滥用的发展。 公共卫生相关性：所要求的仪器系统将用于对人类健康具有重要意义的项目，例如：神经艾滋病、结核病、疟疾和其他传染病的发病机理;糖尿病和肥胖症、癌症;以及神经传递。

DESCRIPTION (provided by applicant): This proposal requests a Thermo Fisher Scientific LTQ Orbitrap Velos mass spectrometer system that will be utilized in projects important to human health, for example: pathogenesis of neuro-AIDS, tuberculosis, malaria and other infectious diseases; diabetes and obesity, cancer; and neurotransmission. The requested instrument is the next generation Orbitrap instrument that has features making it ideally suited for the projects proposed. These projects emphasize studies of quantitative proteomics and posttranslational modifications. This instrument will be utilized in an established mass spectrometry resource laboratory with highly skilled staff scientists in a highly interactive environment. The instrument system will also benefit the recently funded Einstein NIDA Proteomics Center on development of NeuroAIDS and drug abuse. PUBLIC HEALTH RELEVANCE: The requested instrument system will be utilized in projects important to human health, for example: pathogenesis of neuro-AIDS, tuberculosis, malaria and other infectious diseases; diabetes and obesity, cancer; and neurotransmission.