Bioenergetics in Health and Diseases

摘要 要求为题为“健康和疾病中的生物能量学”的Keystone专题讨论会提供支助， 由Shingo Kajimura，安娜Krook和Jared Rutter博士组织。会议将在Keystone举行， 科罗拉多，2023年1月15日至19日。 生物能量缺陷是代谢疾病、年龄相关疾病和癌症的核心;然而， 启动过程仍然没有得到充分的理解。在过去的几年里，该领域一直是 由于几项突破而转变，并继续扩大。例如， 确定了无效循环。线粒体代谢的新调节因子及其在代谢中的作用 疾病和癌症的报道。代谢组学、脂质组学和 蛋白质组学技术正在迅速发展。因此，有势头组织一次会议， 在代谢性疾病、运动和癌症的背景下关注这一令人兴奋的新兴话题。的 该计划包括一个多学科的演讲阵容，将涵盖的主题，如线粒体生物能量学， 癌症代谢、运动生理学和代谢性疾病。此外，本次会议将在 与Keystone研讨会会议联合举办，“脂肪组织：为好脂肪提供能量”。这一组合将 特色三个共享会议：健康和疾病的代谢通量，生物能量学和能量稳态， 脂肪组织和代谢疾病。预计这些主题将创造许多新的 合作和跨学科的互动。总而言之，本次会议旨在讨论 在代谢疾病的背景下，在分子和生物能量学领域出现的问题， 生物体水平，除了促进在该领域的既定和新的调查人员之间的协同作用， 能量代谢

ABSTRACT Support is requested for a Keystone Symposia conference entitled Bioenergetics in Health and Diseases, organized by Drs. Shingo Kajimura, Anna Krook and Jared Rutter. The conference will be held in Keystone, Colorado from January 15-19, 2023. Bioenergetic defects lie at the heart of metabolic disease, age-related disease, and cancer; however, what initiates the processes remain insufficiently understood. Over the last several years, the field has been transformed because of several breakthroughs and continues to expand. For instance, new mechanisms of futile cycling were identified. Novel regulators of mitochondrial metabolism and their roles in metabolic diseases and cancer have been reported. The sensitivity and resolution of metabolomics, lipidomics, and proteomics technologies are rapidly increasing. Thus, there is momentum to organize a conference that focuses on this exciting and emerging topic in the context of metabolic diseases, exercise, and cancer. The program includes a multi-disciplinary speaker lineup that will cover topics such as mitochondrial bioenergetics, cancer metabolism, exercise physiology, and metabolic diseases. Moreover, this conference will be held jointly with the Keystone Symposia conference, “Adipose Tissue: Energizing Good Fat.” This pairing will feature three shared sessions: Metabolic Flux in Health and Disease, Bioenergetics and Energy Homeostasis, and Adipose Tissue and Metabolic Diseases. It is anticipated that these topics will create numerous new collaborations and cross-disciplinary interactions. All in all, this conference was designed to discuss the emerging questions in the field of bioenergetics in the context of metabolic diseases at molecular and organismal levels, in addition to facilitating synergy between established and new investigators in the field of energy metabolism.