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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号：
7733329
负责人：
Heidi Kong
金额：
$1.17万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7733329
关键词：
BiopsyClinicalComputer softwareComputersCutaneousCytochrome P450Data AnalysesDiureticsDoxycyclineEquipmentGene ExpressionGene Expression ProfilingGenotypeGoalsLightMicroarray AnalysisNon-Steroidal Anti-Inflammatory AgentsPathway interactionsPharmaceutical PreparationsPhasePhotographyPhototoxicityProceduresRNAReactionRecommendationRoleSkinSunscreening AgentsTestingUltraviolet RaysVisible RadiationVoriconazoleantimicrobialhealthy volunteerhuman subjecttranslational approachultraviolet

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中文摘要
翻译
在2008财年，我们完成了对服用多西环素前后的人体受试者的光测试，以获得多西环素引起的皮肤光毒性和皮肤活检的临床信息，用于微阵列分析。光测试程序使用了1)带有不同紫外线和滤光片的太阳模拟器、2)摄影设备和3)色度计。皮肤活检组织经过了核糖核酸(RNA)分离，然后在微阵列芯片上进行杂交。该项目目前正处于微阵列数据分析阶段，这需要足够强大的计算机设备和软件。
英文摘要
In fiscal year 2008, we finalized phototesting of human subjects before and after doxycycline ingestiont to obtain clinical information on doxycycline-induced cutaneous phototoxicity and skin biopsies for microarray analysis. Phototesting procedures utilized 1) a solar simulator with different ultraviolet and light filters, 2) photography equipment, and 3) a colorimeter. Skin biopsies have undergone ribonucleic acid (RNA) isolation followed by hybrization on microarray chips. The project is currently in the microarray data analysis phase which has required sufficiently-powered computer equipment and software.
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会议论文
Effects of systemic and topical perturbations on human microbes
Botulinum Toxin for Painful Cutaneous Leiomyomas
Gene Expression Profiling and Clinical Characterization of Phototoxicity
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients
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