Triglycerides and Triglyceride-Rich Particles in Health and Disease

描述（由申请人提供）： 这个提议是为了请求对一个名为“健康和疾病中的甘油三酯和富含甘油三酯的颗粒”的Keystone研讨会的支持。埃克尔，伊拉J戈德堡和露丝麦克弗森，这将是在大天空，蒙大拿州举行，从2010年1月9日至14日。甘油三酯是重要的储存分子，在脂质和脂蛋白代谢、胰岛素作用、能量平衡和动脉粥样硬化中起重要作用。本次会议的目的将是严格审查甘油三酯生物学的广谱，从肝和肠中甘油三酯生物合成的分子生物学到脂蛋白组装和分泌，再到脂质燃料分配到脂肪组织，肌肉和肝脏。通过胰岛素和促炎和抗炎细胞因子调节脂肪组织至肝脏的游离脂肪酸流量的讨论将先于乳糜微粒和VLDL转运、血管内脂解和组织特异性脂质分配的详细报道。随着对富含甘油三酯的脂蛋白代谢紊乱的遗传基础和动脉粥样硬化的发病机制的理解的预期更新，将发生向甘油三酯的科学和医学的过渡，动脉粥样硬化的发病机制具体涉及循环的富含甘油三酯的颗粒。高甘油三酯血症的临床相关性，高甘油三酯血症药物治疗机制的新见解，以及降低甘油三酯降低心血管疾病风险的临床试验证据。会议将吸引来自学术界和工业界的基础，临床和人口科学家，并将处理围绕健康和疾病中的甘油三酯和富含甘油三酯的颗粒仍然不清楚或有争议的许多问题。公共卫生相关性：研究表明，甘油三酯是导致冠状动脉疾病的一个原因;然而，降低甘油三酯水平是否具有保护作用仍存在重大问题。此外，有关最严重形式的高胆固醇血症与动脉粥样硬化发展的数据有限。这个关于健康和疾病中甘油三酯和富含甘油三酯的颗粒的Keystone研讨会会议将聚集领先的科学家讨论1）高甘油三酯血症的原因和治疗的临床科学，以及2）甘油三酯如何调节和影响动物和细胞的生物学。

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled Triglycerides and Triglyceride- Rich Particles in Health and Disease, organized by Robert H. Eckel, Ira J. Goldberg and Ruth McPherson, which will be held in Big Sky, Montana from January 9 - 14, 2010. Triglycerides are important storage molecules that play important roles in lipid and lipoprotein metabolism, insulin action, energy balance, and atherosclerosis. The purpose of this meeting will be to critically examine the broad spectrum of triglyceride biology from the molecular biology of triglyceride biosynthesis in the liver and intestine to lipoprotein assembly and secretion to lipid fuel partitioning to adipose tissue, muscle and the liver. A discussion of the regulation of free fatty acid flux from adipose tissue to the liver by insulin and pro- and anti-inflammatory cytokines will precede a detailed coverage of chylomicron and VLDL transport, intravascular lipolysis and tissue-specific lipid partitioning. A transition to the science and medicine of triglycerides will then occur with expected updates on the understanding of the genetic basis of disorders of triglyceride-rich lipoprotein metabolism and the pathogenesis of atherosclerosis that relate specifically to circulating triglyceride-rich particles. The clinical relevance of hypertriglyceridemia, new insights into the mechanisms of pharmacological treatment of hypertriglyceridemia, and clinical trial evidence pro and con that triglyceride lowering reduces cardiovascular disease risk will follow. The meeting should attract basic, clinical, and population scientists from academia and industry, and will deal with the many issues that remain unclear or controversial surrounding triglycerides and triglyceride rich particles in health and disease. PUBLIC HEALTH RELEVANCE: Research suggests that triglycerides are a cause of greater coronary artery disease; however, significant questions remain as to whether or not reducing triglyceride levels is protective. Moreover, the data relating the most severe forms of hypertriglyceridemia to development of atherosclerosis are limited. This Keystone Symposia meeting on Triglycerides and Triglyceride-Rich Particles in Health and Disease will assemble leading scientists to discuss 1) the clinical science on causes and treatment of hypertriglyceridemia, and 2) how triglycerides are regulated and affect biology in animals and cells.