Protection from HIV: Targeted Intervention Strategies

描述（由申请人提供）： 该提案要求支持由Mario Roederer、Carolyn威廉姆森和Robin Shattock组织的题为“保护免受艾滋病毒侵害：有针对性的干预战略”的Keystone专题讨论会会议，该会议将于2011年3月20日至25日在加拿大不列颠哥伦比亚省惠斯勒举行。预防HIV感染的生物学努力集中在四种独立的方法上：通过接种疫苗诱导适应性免疫反应，增强先天性反应，使用暴露前后预防性药物治疗，以及开发杀微生物剂和/或重组抗病毒微生物产品。虽然所有这四种方法都有希望，但它们仍然需要显著的优化和进一步的临床试验。事实上，成功预防艾滋病毒感染可能需要将这些方法结合起来。这种开发工作需要更好地了解传播部位的病毒和免疫事件。本次会议将重点关注粘膜免疫学以及病毒与先天性和适应性免疫反应之间的相互作用，特别是在感染的急性期。该领域的领先专家将讨论这些预防感染的各种方法的最新科学进展，并提供最近临床试验的数据，以测试其疗效。这次会议的计划很有可能吸引各种各样的调查人员，其中许多人可能不会互动。对艾滋病毒疫苗的关注提供了一个保护伞，来自不同研究领域的发言者（例如，传染病、疫苗学、遗传学和基因组学、流行病学、粘膜生物学、免疫学和药物发现）被聚集在一个高度有利于串扰的环境中。此外，跨学科互动的机会将大大提高了艾滋病毒进化，基因组学和发病机制，这将与本次会议共享一个主旨演讲和两个全体会议的同期会议。 项目叙述： 预防仍然是控制并最终根除艾滋病毒流行病的基石。为实现这一目标，需要有一个有针对性的综合干预战略。成功地预防艾滋病毒感染将需要采取综合办法。“保护免受艾滋病毒侵害：有针对性的干预战略”的Keystone专题讨论会不同于其他会议，因为它提供了一个论坛，汇集了艾滋病毒生物医学预防研究领域的所有最新成果。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Protection from HIV: Targeted Intervention Strategies, organized by Mario Roederer, Carolyn Williamson and Robin Shattock, which will be held in Whistler, British Columbia, Canada from March 20 - 25, 2011. Biological efforts to prevent HIV infection center on four independent approaches: inducing adaptive immune responses through vaccination, augmenting innate responses, using peri-exposure prophylactic drug therapy, and developing microbicides and/or recombinant antiviral microbial products. While all four of these approaches have promise, they still require significant optimization and further clinical trials. Indeed, successful prevention of HIV infection will likely require a combination of these approaches. Such development efforts require a better understanding of viral and immunological events at the site of transmission. This meeting will have a focus on mucosal immunology as well as on the interplay between the virus and the innate and adaptive immune responses, particularly during the acute phase of the infection. Leading experts in the fields will discuss recent scientific advances in these varied approaches to preventing infection, and present data from recent clinical trials testing their efficacy. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on HIV vaccines in general provides an umbrella under which speakers from different areas of research (e.g., infectious diseases, vaccinology, genetics and genomics, epidemiology, mucosal biology, immunology, and drug discovery) are being brought together in an environment that is highly conducive to cross-talk. Moreover, opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on HIV Evolution, Genomics, and Pathogenesis, which will share a keynote address and two plenary sessions with this meeting. Project Narrative: Prevention remains the cornerstone of controlling, and eventually eradicating, the HIV epidemic. A targeted, integrated intervention strategy is required to achieve this goal. Successful prevention of HIV infection will require a combination of approaches. The Keystone Symposia meeting on Protection from HIV: Targeted Intervention Strategies differs from other meetings in that it provides a forum to bring together all the latest findings in the field of HIV biomedical prevention research.