Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics

描述(由申请人提供)： 该提案请求支持将于2011年1月15-20日在加拿大不列颠哥伦比亚省温哥华举行的题为《分枝杆菌：生理学、新陈代谢和病因学-回归基础》的Keystone研讨会，该会议由David R.Sherman和Sabine Ehrt组织。本次会议将讨论结核病的基本认识、治疗和预防，重点是结核分枝杆菌的生理、代谢和发病机制。虽然分枝杆菌计划主要关注病原体，但我们计划将这次会议与重点关注宿主的结核病：免疫学、细胞生物学和新型疫苗接种策略的Keystone研讨会会议同时举行。总而言之，这些会议旨在吸引对病原体和宿主为重点的学科感兴趣的科学家，同时每天提供联合会议以鼓励和促进互动。例如，我们将主办一次关于“系统生物学”的联合会议，这是一种刚刚开始应用于结核病研究的创新和强大的方法。联合会议还将讨论结核病的治疗和预防，举行药物和疫苗发现战略会议，以及临床试验能力建设会议。其他联合会议包括对宿主-病原体接口的关注。分枝杆菌会议和结核病会议的配对--将分享一次主旨演讲、4次全体会议和2次研讨会--使这次会议变得独特，并增加了通常不进行互动的研究人员之间的交流机会。分枝杆菌会议旨在提供对结核分枝杆菌生物学和发病机制的最新概述；强调这项工作的翻译影响；为研究人员提供从不同模型系统、主题和研究水平获得相关数据的途径；并帮助确定需要解决的最重要的问题。 项目说明： 结核病是一种毁灭性的全球健康危机，世界上每15秒就有一人死于结核病。经过几十年的忽视，结核病研究近年来获得了越来越多的关注和资源。这种复兴导致了许多关于结核病生物学的重大发现，包括可能导致新的诊断、药物和疫苗的发现。分枝杆菌：生理学、新陈代谢和病因学-回到基础的Keystone研讨会会议将讨论关于结核病的生理学、新陈代谢和发病机制的最新发现。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Mycobacteria: Physiology, Metabolism and Pathogenesis- Back to the Basics, organized by David R. Sherman and Sabine Ehrt, which will be held in Vancouver, British Columbia, Canada from January 15 - 20, 2011. This meeting will address basic understanding, treatment, and prevention of tuberculosis, with a focus on the physiology, metabolism, and pathogenesis of M. tuberculosis. While the Mycobacteria program is primarily pathogen-focused, we have planned this meeting to run in parallel with the Keystone Symposia meeting on Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies, a program focused on the host. In combination, these meetings are designed to attract scientists with interests in both pathogen- and host-focused disciplines, while providing joint sessions each day to encourage and facilitate interactions. For example, we will host a joint session on "Systems Biology", an innovative and powerful approach that is just starting to be applied to TB research. Joint sessions will also address treatment and prevention of tuberculosis with sessions on drug and vaccine discovery strategies, and capacity-building for clinical trials. Other joint sessions include a focus on the host- pathogen interface. The pairing of the Mycobacteria meeting and the meeting on Tuberculosis- which will share a keynote address, 4 plenary sessions, and 2 workshops- renders this meeting unique and enhances opportunities for exchanges between researchers who do not typically interact. The Mycobacteria meeting is intended to provide a state-of-the-art overview of M. tuberculosis biology and pathogenesis; to highlight the translational implications of this work; to provide researchers with access to relevant data from diverse model systems, topics and levels of investigation; and to help define the most important questions to be addressed. Project Narrative: Tuberculosis (TB) is a devastating global health crisis, killing someone in the world every 15 seconds. After decades of neglect, TB research has gained increasing attention and resources in recent years. This resurgence has resulted in many significant findings on the biology of TB disease, including discoveries that may lead to new diagnostics, drugs and vaccines. The Keystone Symposia meeting on Mycobacteria: Physiology, Metabolism and Pathogenesis- Back to the Basics will address the latest findings on the physiology, metabolism, and pathogenesis of TB.