Mucosal Biology: A Fine Balance between Tolerance and Immunity

描述(由申请人提供)： 该提案请求支持将于2011年2月26日至3月3日在加拿大不列颠哥伦比亚省温哥华举行的题为《粘膜生物学：容忍和免疫之间的精细平衡》的Keystone研讨会，该会议由Joanne L.Viney、Paul Garside和Bana Jabri组织。来自粘膜生物学的基础科学和临床领域的专家将与其他科学学科的领导人一起，就调节健康和疾病中粘膜反应的成熟、发展和维持的机制进行富有启发性的讨论。将注意肠道、肺、皮肤、眼睛和生殖道组织。关于新的细胞类型和受体的最新信息，对于调节免疫和加强粘膜保护非常重要。感染对驱动宿主免疫改变的影响将被询问。会议将强调疫苗开发和成像技术的现代方法，并将讨论物理科学和工程学的最新进展，同时我们将展望未来的医疗需求和发展。此外，同时举行的呼吸道免疫：肺环境的挑战会议将大大增加跨学科互动的机会，该会议将与本次会议举行一次主旨演讲和两次全体会议。 项目说明： 人体的粘膜表面必须对潜在的病原体产生保护性免疫反应，同时对有益的抗原保持耐受性，例如食物蛋白质中的那些抗原。有时，耐受性和免疫力之间的平衡被打破，导致慢性炎症性疾病，如肠道的炎症性肠病(IBD)和肺部的慢性阻塞性肺疾病(COPD)。控制宿主细胞是否以及如何启动主动免疫反应的调控机制仍有待充分阐明，帮助避免自身免疫性炎症反应的调控机制也是如此。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Mucosal Biology: A Fine Balance between Tolerance and Immunity, organized by Joanne L. Viney, Paul Garside and Bana Jabri, which will be held in Vancouver, British Columbia, Canada from February 26 - March 3, 2011. Experts from the basic science and clinical fields of mucosal biology will be brought together with leaders from other scientific disciplines for a stimulating discussion on the mechanisms regulating the maturation, development and maintenance of mucosal responses in health and disease. Attention will be given to gut, lung, skin, eye and genitourinary tract tissues. The latest information on novel cell types and receptors important for regulating immunity and enhancing mucosal protection will be presented. The influence of infection on driving altered host immunity will be interrogated. The meeting will highlight modern approaches to vaccine development and imaging technology, and the most up to date advances from the physical sciences and engineering will be discussed as we look to the medical needs and developments of the future. In addition, opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Immunity in the Respiratory Tract: Challenges of the Lung Environment, which will share a keynote address and two plenary sessions with this meeting. Project Narrative: The mucosal surfaces of the body must mount protective immune responses against potential pathogens and, at the same time, remain tolerant to beneficial antigens, such as those in food proteins. On occasion, the balance between tolerance and immunity is upset, resulting in chronic inflammatory disorders such as inflammatory bowel disease (IBD) in the intestine, and chronic obstructive pulmonary disease (COPD) in the lung. The regulatory mechanisms that control whether, and how, host cells mount an active immune response remain to be fully elucidated, as do the regulatory mechanisms that help to avoid autoimmune inflammatory responses.