Myeloid Cells

 说明(由申请人提供)：请求支持由Arturo Zychlinsky、Judith E.Allen、Eicke Latz和Kate A.Fitzgerald组织的题为髓样细胞的Keystone研讨会。会议将于2016年4月10日至14日在爱尔兰基拉尼举行。髓系 细胞在免疫中是必不可少的：它们控制宿主与环境的相互作用，在抗击感染和与免疫系统其他分支的交流中不可或缺。新技术的引入揭示了这些细胞在个体发育、特化、调节和调节适应性免疫方面前所未有的复杂性。这次会议将讨论髓系细胞生物学中的热点问题，包括髓细胞的起源、训练免疫、表观遗传学和对其功能的遗传调节等新概念。它将涵盖骨髓和胎儿来源的髓系细胞，重点介绍巨噬细胞如何与包括粒细胞在内的其他髓系细胞相互作用。还将强调包括医疗干预在内的临床方法。了解髓系反应的多样性和特异性的新方法也将包括在内。研讨会将包括当代免疫学在遗传和细胞水平上的核心不同领域，包括关于健康和疾病中先天免疫的适应性免疫反应的指导。因此，从事细胞生物学、免疫学和传染病研究的基础和临床科学家都应该对此感兴趣。

 DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Myeloid Cells, organized by Arturo Zychlinsky, Judith E. Allen, Eicke Latz and Kate A. Fitzgerald. The meeting will be held in Killarney, Ireland from April 10- 14, 2016. Myeloid cells are essential in immunity: they control the interaction of the host with the environment and are indispensable in fighting infections and in the communication with other branches of the immune system. The introduction of new technology is revealing unprecedented levels of complexity in ontogeny, specialization, regulation and modulation of adaptive immunity by these cells. This meeting will cover topical questions in myeloid cell biology, including new concepts like the origin of myelocytes, trained immunity, epigenetic and genetic regulation of their function. It will cover myeloid cells of both bone marrow and fetal origin with an emphasis on how macrophages interact with other myeloid cells including granulocytes. There will also be an emphasis on clinical approaches including medical intervention. New approaches to understand the diversity and specificity of myeloid responses will be also included. The symposium will include different fields central to contemporary immunology both at the genetic and cellular level, including the instruction of the adaptive immune response by innate immunity in health and disease. It should therefore be of interest to both basic and clinical scientists working in cel biology, immunology and infectious disease.