Hematopoiesis

摘要 请为卡特里奥纳博士组织的题为造血的Keystone研讨会提供支持 H·M·贾米森、安德烈亚斯·特朗普和保罗·S·弗雷内特。会议将在加拿大艾伯塔省的班夫举行 2017年1月31日至2月4日。自从发现造血可以通过一种单一的 细胞五十多年前，在模型系统、测序、重新编程和基因组编辑方面的进展 技术使造血调节因子的精确分子表征成为可能。这些 这些发现为广泛的良性和非传染性疾病的临床试验提供了信息，并加快了临床试验的实施 恶性血液病，包括骨髓衰竭综合征和白血病，以及指导 分子预测策略的发展。这次会议将把基本的、可翻译的 和临床研究人员讨论造血干细胞和祖细胞个体发育、细胞命运的关键调控因素 在动态平衡、应激和恶变过程中的规范和自我更新。相对的 细胞自主遗传、表观遗传、转录和转录后造血的重要性 监管机制以及当地的利基或系统因素将由国际领导人在 造血和干细胞生物学领域。创新基因组编辑的顶峰， 在不同的模型系统中进行重新编程、单细胞测序和成像以解开基本调控因子 造血的重要性将会被凸显出来。我们期待这次会议将提供一个重要的机会， 来自不同学科的研究人员之间的合作，并从过多的 将使研究人员能够处理基础、翻译和临床造血研究的模型系统 挑战。

ABSTRACT Support is requested for a Keystone Symposia meeting entitled Hematopoiesis, organized by Drs. Catriona H.M. Jamieson, Andreas Trumpp and Paul S. Frenette. The meeting will be held in Banff, Alberta, Canada from January 31 – February 4, 2017. Since the discovery that hematopoiesis could be established by a single cell over five decades ago, advances in model systems, sequencing, reprogramming and genome editing technologies have enabled precise molecular characterization of regulators of hematopoiesis. These discoveries have informed and accelerated implementation of clinical trials for a broad of array of benign and malignant hematologic disorders, including bone marrow failure syndromes and leukemia, as well as guided the development of molecular prognostication strategies. This meeting will bring together basic, translational and clinical researchers to discuss key regulators of hematopoietic stem and progenitor cell ontogeny, cell fate specification and self-renewal during homeostasis, stress and malignant transformation. The relative importance of cell-autonomous genetic, epigenetic, transcriptional and post-transcriptional hematopoietic regulatory mechanisms as well as local niche or systemic factors will be presented by international leaders in the field of hematopoiesis and stem cell biology. The culmination of innovative genome editing, reprogramming, single-cell sequencing and imaging in different model systems to unravel essential regulators of hematopoiesis will be highlighted. We anticipate that this meeting will provide a vital opportunity for forging collaborations between researchers from disparate disciplines and result in novel insights from a plethora of model systems that will enable investigators to address basic, translational and clinical hematopoiesis research challenges.