Quantitative neuroreceptor imaging for mice using PET : development of micro litter ordered blood radioactivity counting system and the technique to omit arterial blood sampling

本文对微升定形血放射性计数系统的方法进行了研究。同时，研究了省略动脉血采样的算法。为了使用正电子发射断层扫描（PET）进行完全定量的功能成像，需要动脉血中的放射性浓度，因此应进行动脉血采样。然而，由于小鼠的体积小，动脉血液采样是PET定量测量的一个问题。本研究旨在实现小鼠的定量PET功能成像，研究了基于MAP估计的几微升动脉血放射性浓度测量系统和降低小鼠PET数据噪声的算法。

In this study, the methods for radioactivity counting system for micro-liter ordered blood were investigated. Also, the algorithm to omit arterial blood sampling was studied. For fully quantitative functional imaging using positron emission tomography (PET), the radioactivity concentration in arterial blood is required, and therefore, arterial blood sampling should be conducted. However, due to the small size in mice, the arterial blood sampling is an issue for PET quantitative measurement. This study aimed to realize quantitative PET functional imaging for mice, the system to measure radioactivity concentration in a few micro-liter arterial blood and the algorithm fo reduce the noise in PET data derived from mice based on MAP estimation were investigated.