Quantitative neuroreceptor imaging for mice using PET : development of micro litter ordered blood radioactivity counting system and the technique to omit arterial blood sampling

本文对微量有序血放射性计数系统的方法进行了研究。此外，算法省略动脉血采样进行了研究。对于使用正电子发射断层扫描（PET）的全定量功能成像，需要动脉血中的放射性浓度，因此，应进行动脉血采样。然而，由于小鼠的体积小，动脉血液采样是PET定量测量的一个问题。本研究以实现小鼠PET定量功能成像为目的，研究了小鼠动脉血中放射性浓度的测量系统和基于MAP估计的小鼠PET数据去噪算法。

In this study, the methods for radioactivity counting system for micro-liter ordered blood were investigated. Also, the algorithm to omit arterial blood sampling was studied. For fully quantitative functional imaging using positron emission tomography (PET), the radioactivity concentration in arterial blood is required, and therefore, arterial blood sampling should be conducted. However, due to the small size in mice, the arterial blood sampling is an issue for PET quantitative measurement. This study aimed to realize quantitative PET functional imaging for mice, the system to measure radioactivity concentration in a few micro-liter arterial blood and the algorithm fo reduce the noise in PET data derived from mice based on MAP estimation were investigated.