Investigation of relationship between the liver and spleen via the portal circulation in sepsis

脓毒症门脉循环肝脾关系的探讨

• 批准号: 21591745
• 负责人: KONO Hiroshi
• 金额: $ 2.91万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591745/
• 关键词: 腹膜炎; 自然免疫; マクロファージ; 膵臓; 臓器相関; Kupffer細胞; NMGB1; 脾臓; 細菌性腹膜炎; 炎症性サイトカイン; HMGB1; kupffer細胞; 脾臓マクロファージ; 脾臓摘出

The purpose of this study was to investigate whether inhibition of Kupffer cells(KCs) affects the expression of HMGB1 and mortality in septic peritonitis. Furthermore, the role of the spleen in septic peritonitis was also investigated. Elimination of the Kupffer cells increased mortality significantly. Furthermore, on the other hand, splenectomy improved mortality in animals with or without KC inhibition after CLP. Thus, the liver and spleen play key roles in host defense during septic peritonitis.

本研究的目的是探讨抑制库普弗细胞（KCs）是否影响脓毒症腹膜炎中HMGB1的表达和死亡率。此外，还研究了脾脏在化脓性腹膜炎中的作用。消除库普弗细胞会显着增加死亡率。此外，另一方面，脾切除可提高 CLP 后有或没有 KC 抑制的动物的死亡率。因此，肝脏和脾脏在脓毒性腹膜炎期间的宿主防御中发挥关键作用。

项目成果

Dietary medium-chain triglycerides prevent chemically induced experimental colitis in rats

• DOI: 10.1016/j.trsl.2009.08.011
• 发表时间: 2010-03-01
• 期刊: TRANSLATIONAL RESEARCH
• 影响因子: 7.8
• 作者: Kono, Hiroshi;Fujii, Hideki;Ogiku, Masahito
• 通讯作者: Ogiku, Masahito

Inhibition of the Kupffer cell increases serum high mobility group box 1levels in a rat septic peritonitis model

抑制库普弗细胞可增加大鼠败血性腹膜炎模型中血清高迁移率族蛋白 1 的水平

• 发表时间: 2009
• 期刊: Journal of Surgical Research (In press)
• 作者: Ishii K;Kono H;Hosomura N;Tsuchiy a M;Ohgiku M;Tanaka N;Fujii H;Masahito Ogiku;Hidetake Amemiya;Nobuyuki Tanaka;Hiroshi Kono
• 通讯作者: Hiroshi Kono

The Kupffer Cell Inhibition Exacerbates but Splenectomy Prevents Mortality in a Rat Septic Peritonitis Model

• DOI: 10.1016/j.jss.2011.02.031
• 发表时间: 2012-06-01
• 期刊: JOURNAL OF SURGICAL RESEARCH
• 影响因子: 2.2
• 作者: Kono, Hiroshi;Fujii, Hideki;Hosomura, Naohiro
• 通讯作者: Hosomura, Naohiro

Role of Macrophage Colony-Stimulating Factor in Polymicrobial Sepsis According to Studies Using Osteopetrotic (op/op) Mice

根据骨质疏松 (op/op) 小鼠的研究，巨噬细胞集落刺激因子在多种微生物败血症中的作用

• 发表时间: 2011
• 期刊: Journal of Surgical Research
• 影响因子: 2.2
• 作者: 堀川昌宏・飯沼久恵;他;Masahito Ogiku
• 通讯作者: Masahito Ogiku

細菌性腹膜炎における肝臓と脾臓マクロファージの役割-門脈を介した肝脾臓器相関

肝脾巨噬细胞在细菌性腹膜炎中的作用-门静脉肝脾器官相关性

• 发表时间: 2011
• 作者: Iinuma H;Watanabe T;et al.;河野寛,大菊雅人,原倫生,土屋雅人,藤井秀樹
• 通讯作者: 河野寛,大菊雅人,原倫生,土屋雅人,藤井秀樹