Investigation of relationship between the liver and spleen via the portal circulation in sepsis
Investigation of relationship between the liver and spleen via the portal circulation in sepsis
批准号:
21591745
负责人:
KONO Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The purpose of this study was to investigate whether inhibition of Kupffer cells(KCs) affects the expression of HMGB1 and mortality in septic peritonitis. Furthermore, the role of the spleen in septic peritonitis was also investigated. Elimination of the Kupffer cells increased mortality significantly. Furthermore, on the other hand, splenectomy improved mortality in animals with or without KC inhibition after CLP. Thus, the liver and spleen play key roles in host defense during septic peritonitis.
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DOI:
10.1016/j.trsl.2009.08.011
发表时间:
2010-03-01
期刊:
TRANSLATIONAL RESEARCH
影响因子:
7.8
作者:
[Kono, Hiroshi, Fujii, Hideki, Ogiku, Masahito]
通讯作者:
Ogiku, Masahito
Inhibition of the Kupffer cell increases serum high mobility group box 1levels in a rat septic peritonitis model
抑制库普弗细胞可增加大鼠败血性腹膜炎模型中血清高迁移率族蛋白 1 的水平
DOI:
--
发表时间:
2009
期刊:
Journal of Surgical Research (In press)
影响因子:
--
作者:
[Ishii K, Kono H, Hosomura N, Tsuchiy a M, Ohgiku M, Tanaka N, Fujii H, Masahito Ogiku, Hidetake Amemiya, Nobuyuki Tanaka, Hiroshi Kono]
通讯作者:
Hiroshi Kono
DOI:
10.1016/j.jss.2011.02.031
发表时间:
2012-06-01
期刊:
JOURNAL OF SURGICAL RESEARCH
影响因子:
2.2
作者:
[Kono, Hiroshi, Fujii, Hideki, Hosomura, Naohiro]
通讯作者:
Hosomura, Naohiro
Role of Macrophage Colony-Stimulating Factor in Polymicrobial Sepsis According to Studies Using Osteopetrotic (op/op) Mice
根据骨质疏松 (op/op) 小鼠的研究,巨噬细胞集落刺激因子在多种微生物败血症中的作用
DOI:
--
发表时间:
2011
期刊:
Journal of Surgical Research
影响因子:
2.2
作者:
[堀川昌宏・飯沼久恵, 他, Masahito Ogiku]
通讯作者:
Masahito Ogiku
細菌性腹膜炎における肝臓と脾臓マクロファージの役割-門脈を介した肝脾臓器相関
肝脾巨噬细胞在细菌性腹膜炎中的作用-门静脉肝脾器官相关性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Iinuma H, Watanabe T, et al., 河野寛,大菊雅人,原倫生,土屋雅人,藤井秀樹]
通讯作者:
河野寛,大菊雅人,原倫生,土屋雅人,藤井秀樹
共 18 条
Effects of PACAP on sptic peritonitis
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批准号:17K10508
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依托单位:
Development of zirconia implant fixture with guided bone regeneration ability
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批准号:24592960
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Automatic Generation of CG Lip Movements Based on Individuals Face
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Development of zirconia complex for metal free restoration
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批准号:21791911
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:KONO Hiroshi
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依托单位:
Investigation of organ interaction in the innate immune system during inflammation
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批准号:19591579
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:KONO Hiroshi
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依托单位:
Investigation of heterogeneity of tissue macrophages and inflammatory immune response during infection.
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批准号:15591394
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:KONO Hiroshi
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依托单位:
Role of the Kupffer cell in hepatic carcinogenesis in patients infected with hepatitis C virus
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批准号:13671293
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:KONO Hiroshi
-
依托单位:
国内基金
海外基金
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