Design of Molecular Assembly for Extraction of Biomolecules

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Liquid/liquid extraction is one of the useful separation techniques involving a molecular recognition event. Despite a number of studies on liquid/liquid extraction, it is still a challenge to extract a target biomolecule selectively to another phase based on the precise recognition at a liquid/liquid interface. In particular, if the target is a biomacromolecule, the presence of multifunctional groups prevents selectivity and versatility in liquid/liquid extraction. We here propose the sequence-specific liquid/liquid extraction of DNA oligonucleotides using reverse micelles with a DNA-surfactant. A reverse micelle, which is a nanoscale water pool surrounded by surfactant molecules in an organic solvent, is one of the highly useful tools for extraction of biomolecules.