Inborn Errors In Immunity

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ABSTRACT Support is requested for a Keystone Symposia conference entitled Inborn Error of Immunity, organized by Drs. Dusan Bogunovic, Isabelle Meyts and Steven Holland. The conference will be a virtual event from October 17- 19, 2022. Inborn errors of immunity (IEIs) are a growing group of over 400 genetic disorders in which individuals present with immune deficiency, immune dysregulation, or both. IEIs combine genomics, next generation transcriptomics and epigenomics, biochemistry, as well as innate and adaptive immunology research, with diverse aspects of clinical medicine ranging from clinical genetics and immunology to metabolism, neurology and dermatology, to name only a few. Bridging these canonically isolated fields into a coherent collaborative scientific enterprise is both essential and a challenge. The historical landscape in IEI has been dominated by concepts of immune deficiency and ensuing susceptibility to infections, but recent discoveries have uncovered genetic errors predisposing to autoinflammatory diseases, and perhaps most surprising those that predispose individuals to both infection and inflammation. The conference is focused on showcasing the genetic errors of the immune system affecting both the innate and adaptive branches. Moreover, it will greatly evolve this emerging field by identifying, studying and crosspollinating studies which discuss both pro- and anti- inflammatory and infectious immune effectors. Finally, this program will also address knowledge gaps in pathways that regulate these immune effectors and suggest rational approaches to target these in patients.