POST-INFLAMMATORY COMPLICATIONS IN UVEITIS

葡萄膜炎的炎症后并发症

• 批准号: 3898144
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3898144
• 关键词: cell membrane; choroid uvea; glia; gliosis; histochemistry /cytochemistry; human tissue; immunochemistry; inflammation; medical complication; retina; scars; uveitis; visual photoreceptor

Complications of post-inflammation in uveitis patients includes destruction of photoreceptors, gliosis, choroidal scar, and formations of cyclitic membrane, snowbanking, and preretinal membrane. Post-inflammatory membrane composition may play an important role in the cause of complications associated with uveitis. In this study, eyes enucleated from patients with end stages of chronic anterior uveitis (formation of cyclitic membrane), pars planitis (formation of preretinal membrane) were evaluated immunohistochemically. Glial cells and proliferating Muller cells were the major cellular components in these membranes. Basement membrane-like components and new collagens were the major extracellular membrane components.

葡萄膜炎患者炎症后的并发症包括破坏 光感受器，神经胶质增生，脉络膜瘢痕，和形成的环状 膜、雪堆和视网膜前膜。 炎后膜 成分可能在引起并发症中起重要作用 与葡萄膜炎有关。 在这项研究中， 慢性前葡萄膜炎的末期（环状膜的形成）， 平坦部炎（视网膜前膜的形成）进行了评价 化学上。 神经胶质细胞和增殖的Muller细胞是神经胶质细胞的主要来源。 这些细胞膜中的主要细胞成分。 基底膜样 细胞外膜主要由胶原和胶原组成 件.