CYTOKINES AND OCULAR ANTIGENS IN THE EYE

眼睛中的细胞因子和眼抗原

• 批准号: 3877080
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3877080
• 关键词: T lymphocyte; antigens; autoimmune disorder; cell cell interaction; crystallins; cytokine; eye disorder; gene expression; human fetus tissue; human tissue; inflammation; interleukin 1; iris; laboratory rat; leukocyte activation /transformation; mammalian embryology; neutrophil; retinoblastoma; tissue /cell culture; uveitis

Cytokines are communication signals between leukocytes and organ resident cells. Interleukin 1 (IL-1) a pleiotropic cytokine produced by many cell types, most notably macrophages, can stimulate a general inflammatory reaction by causing the activation of a variety of cells which then, among their other functions, release a cascade of other cytokines. One of them is Interleukin 8 (IL-8), which has more direct action of activating the neutrophils and T lymphocytes. Intravitreal injection of IL-8 was compared to that of IL-1 in both Lewis and Fischer rats. IL-8 induced milder inflammation than IL-1. Lewis rats show a higher inflammatory response to the injections than do Fischer rats. These data suggest that IL-8 may be active as one component in neutrophil-mediated ocular disease. Further understanding of the role of each cytokine in ocular inflammation, will require study of the production of endogenous cytokines in the eye. Ocular antigens play an important role in autoimmune diseases. S-antigen (S-Ag), a retinal soluble antigen, can induce experimental autoimmune uveoretinitis. In situ, study of S-Ag expression in human fetal eyes demonstrated an embryonic development pattern similar to that of other mammals. The expression of S-Ag in RNA of non-retinal fetal tissues may suggest its involvement in certain ocular diseases. Lens crystallin proteins alpha, beta and gamma were also found in human fetal iris and retinoblastoma cells. The roles of their expression in non-lenticular tissue require further investigation.

细胞因子是白细胞与器官驻留细胞之间的通讯信号 细胞白细胞介素1（IL-1）是一种由多种细胞产生的多效性细胞因子， 类型，最明显的是巨噬细胞，可以刺激全身炎症， 反应通过引起各种细胞的激活，然后， 它们的其他功能，释放一系列其他细胞因子。其中之一是 白细胞介素8（IL-8），它具有更直接的激活作用， 中性粒细胞和T淋巴细胞。玻璃体腔内注射IL-8， 刘易斯和费舍尔大鼠中IL-1的表达。IL-8诱导的轻度 炎症比IL-1。刘易斯大鼠对 比费希尔大鼠更容易注射这些数据表明，IL-8可能是 作为中性粒细胞介导的眼部疾病的一种成分而活跃。进一步 了解每种细胞因子在眼部炎症中的作用， 需要研究眼内内源性细胞因子的产生。 眼抗原在自身免疫性疾病中起重要作用。s抗原 视网膜可溶性抗原（S-Ag）可诱导实验性自身免疫反应 葡萄膜视网膜炎人胎眼S-Ag表达的原位研究 证明了一种类似于其他物种的胚胎发育模式 哺乳动物S-Ag在非视网膜胚胎组织RNA中的表达可能与其在视网膜发育中的作用有关。 表明它与某些眼部疾病有关。透镜晶体蛋白 蛋白质α、β和γ也在人类胎儿虹膜中发现， 视网膜母细胞瘤细胞它们的表达在非豆状核变性中的作用 组织需要进一步研究。