IMMUNOPATHOLOGY IN THE EYES WITH EXPERIMENTAL AUTOIMMUNE UVEITIS

免疫活性细胞的识别和地形图定位 啮齿动物眼部驻留细胞表面标志物的变化 主动免疫治疗实验性自身免疫性葡萄膜视网膜炎 采用免疫组织化学方法进行分析。 炎症部位的淋巴细胞群被发现 在疾病过程中发生显著变化。在早期阶段， 辅助性T细胞/诱导性T细胞是眼内的主要细胞。一位亲戚 晚期T-抑制/细胞毒细胞增多 观察到的。主要组织相容性复合体II类的表达 眼部常驻细胞上的抗原，如RPE，视网膜内皮， 角膜基质细胞、成纤维细胞和睫状体上皮细胞。 大鼠不同的EAU模型。这种抗原表达可能在 在EAU的发病机制中具有一定的作用。两者均为浸润性(细胞 亚群)和眼部II类抗原的表达 驻留细胞，可以被不同的免疫抑制物调节 探员们。 S抗原特异性过继转移诱导EAU的动态变化 T淋巴细胞株已表明，该细胞系可以识别 体内的光感受器S-Ag。青光眼的免疫病理学研究 小鼠的EAU可表现为慢性肉芽肿 发炎。视网膜下新生血管的发展可能 发生。主要组织相容性复合体II类的表达 抗原仅存在于眼部驻留细胞上 炎性细胞。

Identity and topographic localization of immunocompetent cells and alteration of surface markers on ocular resident cells in rodents with experimental autoimmune uveoretinitis by active immunization or adoptive transfer were analyzed by immunohistochemical studies. The lymphocyte population at the inflammatory sites was found to change markedly during the course of disease. In the early stage, T-helper/inducers are the predominant cells in the eye. A relative increase of T-suppressor/cytotoxic cells in the late stage were observed. Expression of major histocompatibility complex class II antigens on ocular resident cells such as RPE, retinal endothelium, keratocytes, fibroblast and ciliary epithelium was observed in different models of EAU in rats. This antigen expression may play a certain role in the pathogenesis of EAU. Both infiltrating (cell subpopulation) and expression of class II antigens on ocular resident cells, can be modulated by different immunosuppressive agents. Dynamics of EAU induced by adoptive transfer of S-antigen-specific T-lymphocyte cell line has showed that this cell line can recognize the photoreceptor S-Ag in vivo. Immunopathology in the eyes with EAU in mice can be presented as a chronic granulomatous inflammation. Development of subretinal neovascularization may occur. Expression of major histocompatibility complex class II antigens is only located on ocular resident cells with the presence of inflammatory cells.