SYMPATHETIC OPHTHALMIA--IMMUNOPATHOLOGICAL FINDINGS

交感性眼炎--免疫病理学发现

• 批准号: 3918823
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918823
• 关键词: B lymphocyte; Freund's adjuvant; T lymphocyte; autoimmune disorder; eye disorder diagnosis; histochemistry /cytochemistry; histopathology; human tissue; immunochemistry; macrophage

Immunocompetent cells and ocular resident cells in the ocular tissues from patients with a clinical diagnosis of sympathetic ophthalmia were examined using the immunohistochemical technique. The choroidal infiltrates were composed primarily of T-lymphocytes. Different amounts of macrophages and B lymphocytes were present in each case. A varied spectrum of immunopathological and histopathological findings may occur in clinically diagnosed sympathetic ophthalmia. The immunopathology resembles EAU induced by retinal soluble model. Exposure of uveal tissue outside the eye and adjuvant effect may be important in the pathogenesis of this disease in humans.

眼内的免疫活性细胞和眼内驻留细胞 临床诊断为交感神经病变的患者的组织 用免疫组织化学技术检测眼炎。 脉络膜浸润物主要由T淋巴细胞组成。 巨噬细胞和B淋巴细胞数量不等。 每一箱都是。不同的免疫病理学和 临床诊断时可出现组织病理学改变 交感性眼炎。免疫病理机制类似于EAU诱导的 视网膜溶解模型。葡萄膜组织暴露在眼外 佐剂作用可能在该病的发病机制中起重要作用。 人类的疾病。