SYMPATHETIC OPHTHALMIA--IMMUNOPATHOLOGICAL FINDINGS

交感性眼炎--免疫病理学发现

• 批准号: 3898143
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3898143
• 关键词: B lymphocyte; Freund's adjuvant; T lymphocyte; autoimmune disorder; eye disorder diagnosis; histochemistry /cytochemistry; histopathology; human tissue; immunochemistry; macrophage

Immunocompetent cells and ocular resident cells in the tissues from patients with a clinical diagnosis of sympathetic ophthalmia were examined immunohistochemically. The choroidal infiltrates were shown to be composed primarily of T-lymphocytes. Different numbers of macrophages and B-lymphocytes were present in each case. A variety of immunopathological and histopathological findings may occur in clinically diagnosed sympathetic ophthalmia. The immunopathology resembles experimental autoimmune uveitis induced by retinal soluble model. Exposure of uveal tissue outside the eye and adjuvant effect may be important in the pathogenesis of this disease in humans.

免疫活性细胞和眼驻留细胞在组织中， 临床诊断为交感性眼炎的患者进行了检查 化学上。 脉络膜浸润被证明是由 主要是T淋巴细胞。 不同数量的巨噬细胞和 B淋巴细胞存在于每种情况下。 多种免疫病理学 临床诊断可能会出现组织病理学改变 交感性眼炎 免疫病理学类似于实验 视网膜可溶性模型诱导的自身免疫性葡萄膜炎。 葡萄膜暴露 眼外组织和辅助作用可能是重要的 这种疾病在人类中的发病机制。